Associations between symptoms of inattention, hyperactivity, restless legs, and periodic leg movements.
Associations between symptoms of inattention, hyperactivity, restless legs, and periodic leg movements.
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DOI：
10.1093/sleep/25.2.213
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发表时间：
2002-03
期刊：
影响因子：
5.6
通讯作者：
R. Chervin;K. Archbold;James E. Dillon;K. Pituch;P. Panahi;R. Dahl;C. Guilleminault
中科院分区：
文献类型：
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作者：
R. Chervin;K. Archbold;James E. Dillon;K. Pituch;P. Panahi;R. Dahl;C. Guilleminault
注意力缺陷多动障碍（ADHD）在小样本的转诊儿童中显示与不宁腿综合征（RLS）和睡眠期间周期性腿部运动（PLMS）有关，但RLS或PLMS是否在多动儿童中更常见尚未得到充分研究。设计：横断面调查。两所大学附属的社区儿科诊所。患者N=866名儿童（469名男孩），年龄2.0 - 13.9岁（平均6.8+/-3.2岁），有门诊预约。干预措施一个有效的儿科睡眠问卷评估PLMS（6项子量表），不宁腿，生长痛，和几个潜在的混淆行为和PLMS或RLS之间的关联。父母还完成了两项常见的行为测量，DSM-IV衍生的注意力不集中/多动量表（IHS）和Conners父母评定量表的多动指数（HI，表示为t分数）。结果17%（95% C.I. [15（20）主题。所有受试者中有13% [11，16]的受试者、18% [12，25]的不宁腿儿童和11% [9，14]的无不宁腿儿童的HI评分为阳性（>60）（卡方p60和以下各项均为：总体PLMS评分增加1.6 [1.4，1.9];不宁腿增加1.9 [1.1，3.2];生长痛增加1.9 [0.9，3.6]（所有年龄和性别调整）。高IHS评分（>1.25）的结果相似。在对嗜睡、打鼾、不安睡眠或兴奋剂使用进行统计学调整后，每种行为测量和PLMS评分之间的关联保持显著性。结论：一般儿科患者的注意力不集中和多动与PLMS和RLS症状相关。如果任何一种情况导致多动症，那么这种关联的程度就表明了一个重要的公共卫生问题。
STUDY OBJECTIVES Attention-deficit/hyperactivity disorder (ADHD) has shown associations with restless legs syndrome (RLS) and periodic leg movements during sleep (PLMS) among small samples of referred children, but whether RLS or PLMS are common more generally among hyperactive children has not been well studied. DESIGN Cross-sectional survey. SETTING Two university-affiliated but community-based general pediatrics clinics. PATIENTS N=866 children (469 boys), aged 2.0 to 13.9 years (mean 6.8+/-3.2 years), with clinic appointments. INTERVENTIONS N/A. MEASUREMENTS A validated Pediatric Sleep Questionnaire assessed for PLMS (a 6-item subscale), restless legs, growing pains, and several potential confounds of an association between behavior and PLMS or RLS. Parents also completed two common behavioral measures, a DSM-IV-derived inattention/hyperactivity scale (IHS) and the hyperactivity index (HI, expressed as a t-score) of the Conners' Parent Rating Scale. RESULTS Restless legs were reported in 17% (95% C.I. [15, 20]) of the subjects. Positive HI scores (>60) were found in 13% [11, 16] of all subjects, 18% [12, 25] of children with restless legs, and 11% [9, 14] of children without restless legs (chi-square p60 and each of the following were: a one-s.d. increase in the overall PLMS score, 1.6 [1.4, 1.9]; restless legs, 1.9 [1.1, 3.2]; and growing pains, 1.9 [0.9, 3.6] (all age and sex-adjusted). Results were similar for high IHS scores (>1.25). The associations between each behavioral measure and the PLMS score retained significance after statistical adjustment for sleepiness, snoring, restless sleep in general, or stimulant use. CONCLUSIONS Inattention and hyperactivity among general pediatric patients are associated with symptoms of PLMS and RLS. If either condition contributes to hyperactivity, the magnitude of association suggests an important public health problem.