Liver toxicity of ionic (Diatrizoate) and nonionic (C-29) contrast materials: effects of serum enzymes after hepatic artery injection in the rat.
Liver toxicity of ionic (Diatrizoate) and nonionic (C-29) contrast materials: effects of serum enzymes after hepatic artery injection in the rat.
复制标题
离子型（泛影酸盐）和非离子型（C-29）造影剂的肝毒性：大鼠肝动脉注射后血清酶的影响。
DOI：
10.1097/00004424-198011000-00007
复制
发表时间：
1980
影响因子：
6.7
通讯作者：
B. Lindell
中科院分区：
文献类型：
--
作者：
K. Mare;T. Almén;B. Lindell
将导管以逆行方向放置在手术暴露的大鼠胃十二指肠动脉中。三分之一的动物术后早期死亡。将导管外置在尾部，并使用一种实验性非离子造影剂（C-29）和一种离子造影剂（泛影葡胺）进行肝脏动脉灌注。以4 ml/kg大鼠的剂量注射两种造影剂（370 mg I/ml）。造影剂注射未引起酶ALAT、ASAT或GT的血清水平发生显著变化。
Catheters were placed in the retrograde direction in the surgically exposed gastroduodenal arteries of rats. There was an early postoperative mortality of one-third of the animals. The catheter was exteriorized at the tail and was used for arterial perfusion of the liver with one experimental, nonionic contrast medium (C-29) and one ionic contrast medium (diatrizoate). Both contrast media (370 mg I/ml) were injected in a dose of 4 ml/kg rat. The contrast medium injections caused no significant changes in serum levels of the enzymes ALAT, ASAT, or GT.