A diffusion tensor imaging study of white matter in obsessive-compulsive disorder
A diffusion tensor imaging study of white matter in obsessive-compulsive disorder
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DOI：
10.1002/da.20246
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发表时间：
2007-01-01
影响因子：
7.4
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
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作者：
Cannistraro, Paul A.;Makris, Nikos;Rauch, Scott L.
我们的目的是测试强迫症（OCD）和健康对照受试者之间的扣带束（CB）和内囊前肢（ALIC）内的白色物质结构的差异。我们研究了8例活动性强迫症患者和10名匹配的健康对照者，使用1.5 T（特斯拉）的扩散张量磁共振成像（DT-MRI）。在CB和ALIC中评价分数各向异性（FA）。采用体素和感兴趣区域两种分析方法。在左侧CB和左侧ALIC中，OCD受试者的FA显著高于健康对照组。在装配CB中，与健康对照组相比，强迫症受试者的FA显著降低。此外，强迫症组表现出异常的不对称性（左>右）的FA在CB。这些结果提供了初步的证据，异常的CB和ALIC的结构在强迫症。FA在这些领域的差异是一致的存在异常连接的节点之间连接这些束。这可以解释为什么手术切断这些纤维束是治疗性的。需要进一步的研究来复制这些发现，并阐明其病理和临床意义。抑郁和焦虑24：440-446，2007. Publisbed 2006 Wiley-Liss，Inc.
Our objective was to test for differences between subjects with obsessive-compulsive disorder (OCD) and healthy controls with respect to white matter architecture within the cingulum bundle (CB) and anterior limb of the internal capsule (ALIC). We studied eight subjects with active OCD and 10 matched healthy controls using diffusion tensor magnetic resonance, imaging (DT-MRI) at 1.5 T (Tesla). Fractional anisotropy (FA) was evaluated in both CB and ALIC. Both voxelwise and region-of-interest methods of analysis were employed. Within both the left CB and the left ALIC, subjects with OCD exhibited significantly greater FA than healthy controls. In the rig-fit CB, subjects with OCD exhibited significantly decreased FA versus healthy control subjects. Additionally, the OCD group exhibited abnormal asymmetry (left > right) of FA in the CB. These results provide preliminary evidence for abnormal architecture within the CB and ALIC in OCD. FA differences in these areas are consistent with the presence of abnormal connections between the nodes linked by these tracts. This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance. Depression and Anxiety 24:440-446, 2007. Publisbed 2006 Wiley-Liss, Inc.