Clustal Omega for making accurate alignments of many protein sequences
Clustal Omega for making accurate alignments of many protein sequences
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DOI：
10.1002/pro.3290
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发表时间：
2018-01-01
期刊：
影响因子：
8
通讯作者：
Higgins, Desmond G.
中科院分区：
文献类型：
--
作者：
Sievers, Fabian;Higgins, Desmond G.
Clustal Omega是一个广泛使用的包进行多序列比对。在这里，我们描述了一些最近添加到包中的内容，并对一些进行校准的替代方法进行了基准测试。这些基准是基于蛋白质结构的比较或预测，包括最近描述的基于二级结构预测的方法。一般来说，Clustal Omega的速度足够快，可以进行非常大的比对，与其他包装相比，蛋白质比对的准确性也很高。该软件包可以作为可执行文件或源代码从各种站点免费获得，也可以从各种站点（尤其是EBI）在线运行。
Clustal Omega is a widely used package for carrying out multiple sequence alignment. Here, we describe some recent additions to the package and benchmark some alternative ways of making alignments. These benchmarks are based on protein structure comparisons or predictions and include a recently described method based on secondary structure prediction. In general, Clustal Omega is fast enough to make very large alignments and the accuracy of protein alignments is high when compared to alternative packages. The package is freely available as executables or source code from or can be run on-line from a variety of sites, especially the EBI .