EFFECTS OF SEX, THYRO-PARATHYROIDECTOMY, AND LIGHT REGIME ON LEVELS AND CIRCADIAN-RHYTHMS OF WHEEL-RUNNING IN RATS
EFFECTS OF SEX, THYRO-PARATHYROIDECTOMY, AND LIGHT REGIME ON LEVELS AND CIRCADIAN-RHYTHMS OF WHEEL-RUNNING IN RATS
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DOI：
10.1016/0031-9384(89)90001-2
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发表时间：
1989-09-01
影响因子：
2.9
通讯作者：
MCEACHRON, DL
中科院分区：
文献类型：
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作者：
SCHULL, J;WALKER, J;MCEACHRON, DL
正常和摘除甲状旁腺(TPX)的SD大鼠，雌雄不拘，在12：12的光暗周期下观察24天，然后在恒定暗红光下观察20天(Free-Run)。研究了轮子运动的昼夜节律周期和水平。完整雌性和雄性TPX的活动显著高于完整雄性，自由奔跑的昼夜节律周期显著缩短，且雌性和雄性的作用不同。雌性TPX的昼夜节律略短于完整雌性，但不显著，雌性TPX的活性水平与雄性有所不同。与完整雌性相比，TPX雌性的昼夜节律周期略短，但不明显，而且与完整雌性相比，TPX雌性的活动水平没有明显的抑制。研究还发现，与完整的动物相比，TPX动物的昼夜活动水平差异更大，特别是在夹带期间，这表明TPX可能对某些光的影响更敏感。对三苯氧胺的影响有许多可能的解释，包括甲状腺和降钙素水平的变化，与性腺激素的相互作用，以及甲状腺激素对昼夜节律系统的可能发育影响。也有可能节律的变化是活动水平变化的次要因素。据报道，人类躁郁症患者甲状腺、甲状旁腺和钙调节异常的发生率非常高，表现为昼夜睡眠-觉醒节律缩短和活动水平异常，还可能对某些光的影响过敏；此外，抑郁症在女性中占主导地位，而躁狂症在男性中占主导地位。目前的结果表明，甲状腺功能障碍可能是这些异常中的一些，以及这些疾病表现的性别差异的部分原因。
Intact and thyro-parathyroidectomized (TPX) Sprague-Dawley rats of both sexes were observed for 24 days under a 12:12 light:dark cycle (Entrainment), followed by 20 days in constant dim red light (Free-Run). Circadian periods and levels of wheel-running activity were examined. Intact females and TPX males were significantly more active and had significantly shorter free-running circadian periods than intact males, and the effects of TPX in females were different from those in males. Circadian periods in TPX females were slightly, but not significantly, shorter than in intact females, and activity levels in TPX in females were different form those in males. Circadian periods in TPX females were slightly, but not significantly, shorter than in intact females, and activity levels in TPX females were nonsignificantly depressed relative to intact females. It was also found that day versus night activity levels differed more in TPX animals than in intact animals, especially during entrainment, suggesting that TPXs may be more sensitive to some effects of light. A number of possible explanations for the effects of TPX are considered, including changes in thyroid and calcitonin levels, interactions with gonadal hormones, and possible developmental effects of thyroid hormones on the circadian system. It is also possible that rhythm changes are secondary to alterations in activity levels. Human manic depressives reportedly have an unusually high incidence of thyroid, parathyroid, and calcium regulation abnormalities, display shortened circadian sleep-wake rhythms and abnormal levels of activity, and may also be hypersensitive to some effects of light; in addition, depression predominates in women, whereas mania predominates in men. The present results suggest that thyroid dysfunction could be partially responsible for some of these abnormalities, and for sex differences in the manifestations of these disorders.