Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease
Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease
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DOI：
10.4049/jimmunol.178.11.7162
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发表时间：
2007-06-01
影响因子：
4.4
通讯作者：
Miller, Marcia M.
中科院分区：
文献类型：
--
作者：
Shiina, Takashi;Briles, W. Elwood;Miller, Marcia M.
MHC单倍型对鸡感染致癌性马立克氏病疱疹病毒后是否形成肿瘤有显著影响。虽然抗肿瘤形成已被映射到一个亚区的鸡MHC-B区，基因或基因负责尚未确定。该次区域的完整基因图谱一直缺乏。我们已经扩大了MHC-B区的基因图谱超出了92 kb的核心先前报道的另一个单倍型揭示存在46个基因内的242 kb的红原鸡单倍型。尽管MHC-B的结构不同，但许多新发现的基因与其他物种中典型的MHC基因座相关。其他MHC-B基因座是在其他染色体上的MHC旁系同源区域（被认为源自原始免疫防御复合物的古老复制的区域，其中基因在进化过程中经历了差异沉默）中发现的基因的同源物。还有一些基因与哺乳动物中定义NK复合体的基因相似。许多新定位的基因显示等位基因变异性，并属于MHC-B亚区，以前显示影响马立克氏病肿瘤的形成，因此是赋予抗性的基因的候选者。
MHC haplotypes have a remarkable influence on whether tumors form following infection of chickens with oncogenic Marek's disease herpesvirus. Although resistance to tumor formation has been mapped to a subregion of the chicken MHC-B region, the gene or genes responsible have not been identified. A full gene map of the subregion has been lacking. We have expanded the MHC-B region gene map beyond the 92-kb core previously reported for another haplotype revealing the presence of 46 genes within 242 kb in the Red Jungle Fowl haplotype. Even though MHC-B is structured differently, many of the newly revealed genes are related to loci typical of the MHC in other species. Other MHC-B loci are homologs of genes found within MHC paralogous regions (regions thought to be derived from ancient duplications of a primordial immune defense complex where genes have undergone differential silencing over evolutionary time) on other chromosomes. Still others are similar to genes that define the NK complex in mammals. Many of the newly mapped genes display allelic variability and fall within the MHC-B subregion previously shown to affect the formation of Marek's disease tumors and hence are candidates for genes conferring resistance.