Reduction of Dopamine Synaptic Activity: Degradation of 50-kHz Ultrasonic Vocalization in Rats
Reduction of Dopamine Synaptic Activity: Degradation of 50-kHz Ultrasonic Vocalization in Rats
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DOI：
10.1037/a0014593
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发表时间：
2009-04-01
影响因子：
1.9
通讯作者：
Schallert, Timothy
中科院分区：
文献类型：
--
作者：
Clucci, Michelle R.;Ahrens, Allison M.;Schallert, Timothy
声音缺陷在帕金森氏症中普遍存在并使人衰弱。这些缺陷可能与黑质纹状体多巴胺神经元的初始病理和由此导致的多巴胺耗竭有关，从而导致多种功能的精细运动控制功能障碍。虽然动物和人类的发声在许多方面可能不同，但我们在2种帕金森病大鼠模型中评估了复杂的（50 khz）超声交配叫声，包括向内侧前脑束单侧输注6-羟多巴胺和外周给予非运动性剂量的多巴胺拮抗剂氟哌啶醇。我们检查了这些处理对声信号的多个方面的影响。颤音（频率调制）50 khz呼叫的数量显着减少，似乎被更简单的（平坦）呼叫所取代。单频和调频呼叫的带宽和最大强度显著降低，但通话时长没有明显变化。我们的研究结果表明，黑质纹状体多巴胺通路在一定程度上参与精细感觉运动功能，包括USV的产生和复杂性。
Vocal deficits are prevalent and debilitating in Parkinson's disease. These deficits may be related to the initial pathology of the nigrostriatal dopamine neurons and resulting dopamine depletion, which contributes to dysfunction of fine motor control in multiple functions. Although vocalization in animals and humans may differ in many respects, we evaluated complex (50-kHz) ultrasonic mate calls in 2 rat models of Parkinson's disease, including unilateral infusions of 6-hydroxydopamine to the medial forebrain bundle and peripheral administration of a nonakinesia dose of the dopamine antagonist haloperidol. We examined the effects of these treatments on multiple aspects of the acoustic signal. The number of trill-like (frequency modulated) 50-kHz calls was significantly reduced, and appeared to be replaced by simpler (flat) calls. The bandwidth and maximum intensity of simple and frequency-modulated calls were significantly decreased, but call duration was not. Our findings suggest that the nigrostriatal dopamine pathway is involved to some extent in fine sensorimotor function that includes USV production and complexity.