Intensive blood pressure control in patients with acute type B aortic dissection (RAID): study protocol for randomized controlled trial
Intensive blood pressure control in patients with acute type B aortic dissection (RAID): study protocol for randomized controlled trial
复制标题
急性 B 型主动脉夹层 (RAID) 患者的强化血压控制：随机对照试验研究方案
DOI：
10.21037/jtd.2017.03.180
复制
发表时间：
2017-05-01
影响因子：
2.5
通讯作者：
Pan, Kong-Han
中科院分区：
文献类型：
--
作者：
Zhou, Jian-Cang;Zhang, Nan;Pan, Kong-Han
背景资料：血压控制是急性B型主动脉夹层（ABAD）患者的基本治疗，应在整个治疗过程中保持。因此，目前绝大多数指南建议将血压控制在140/90 mmHg以下。从理论上讲，更低的目标可能会进一步降低夹层传播的风险。然而，一些人认为，过低的血压会损害器官灌注。因此，迄今为止，ABAD患者的血压没有一致的最佳目标。本研究旨在探讨ABAD患者的最佳血压目标，以期为主动脉夹层（AD）的治疗提供依据。研究人群将包括新诊断的ABAD和高血压患者。在强化血压控制（
Background: Blood pressure control is an essential therapy for patients with acute type B aortic dissection (ABAD) and should be maintained throughout the entire treatment. Thus, vast majority current guidelines recommend control the blood pressure to lower than 140/90 mmHg. Theoretically, a much lower target may further decrease the risk of propagation of dissection. However, some argued that too lower blood pressure would compromise the organ perfusion. Thus, there is no unanimous optimal target for blood pressure in patients with ABAD so far. The present study aimed to investigate the optimal blood pressure target for patients with ABAD, in the hope that the result would optimize the treatment of aortic dissection (AD).Methods: The study is a multi-center randomized controlled clinical trial. Study population will include patients with new diagnosed ABAD and hypertension. Blocked randomization was performed where intensive blood pressure control (