Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity
Coating of carboxymethyl dextran on liposomal curcumin to improve the anticancer activity
复制标题
脂质体姜黄素包覆羧甲基右旋糖酐提高抗癌活性
DOI：
10.1039/c4ra11181h
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发表时间：
2014-01-01
期刊：
影响因子：
3.9
通讯作者：
Liu, You-Nian
中科院分区：
文献类型：
--
作者：
Huang, Qiyu;Zhang, Lili;Liu, You-Nian
本文利用羧甲基葡聚糖（carboxymethyl dextran， CMD）这一具有生物相容性和可生物降解性的多糖衍生物，对姜黄素脂质体进行修饰，以提高姜黄素的抗癌作用。成功制备了聚乙二醇化姜黄素脂质体（CMD-Cur-Lip），并与未修饰的姜黄素脂质体和两种聚乙二醇化姜黄素脂质体进行了比较。结果表明：(1)经CMD修饰后，姜黄素在脂质体中的包封率提高；(2)载姜黄素脂质体均具有控释特性；(3)与其他脂质体制剂和游离姜黄素相比，CMD-Cur-Lip对癌细胞的细胞毒性有所改善；(4)与其他脂质体制剂相比，CMD-Cur-Lip表现出最高的细胞摄取。
In this work, carboxymethyl dextran (CMD), a polysaccharidic dextran derivative with well-known biocompatibility and biodegradability, was used to modify curcumin-loaded liposomes for improving the anticancer efficacy of curcumin. The CMDylated curcumin-loaded liposomes (CMD-Cur-Lip) were successfully prepared and characterized in comparison with unmodified and two PEGylated curcumin-loaded liposomes. The results showed that: (1) the encapsulation efficiency of curcumin in the liposomes was improved after being modified with CMD; (2) all the curcumin-loaded liposomes displayed controlled release characteristics; (3) the CMD-Cur-Lip demonstrated improved cell cytotoxicity against cancer cells, as compared to other liposomal formulations and free curcumin; (4) CMD-Cur-Lip exhibited the highest cellular uptake as compared to other liposomal formulations.