Detection of gastric cancer using 18F-FLT PET: comparison with 18F-FDG PET
Detection of gastric cancer using 18F-FLT PET: comparison with 18F-FDG PET
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DOI：
10.1007/s00259-008-0970-3
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发表时间：
2009-03-01
影响因子：
9.1
通讯作者：
Nishiyama, Yoshihiro
中科院分区：
文献类型：
--
作者：
Kameyama, Reiko;Yamamoto, Yuka;Nishiyama, Yoshihiro
我们前瞻性地研究了3 '-脱氧-3'-F-18-氟胸苷（FLT）正电子发射断层扫描（PET）检测胃癌的可行性，并与2-脱氧-2-F-18-氟-D-葡萄糖（FDG）PET进行比较，并确定两种放射性示踪剂与增殖活性之间的相关程度，如Ki-17所示。对21例新诊断的进展期胃癌患者进行FLT PET和FDG PET检查。肿瘤病变被确定为局灶性摄取增加的区域，超过周围正常组织。FLT PET和FDG PET诊断进展期胃癌的敏感性分别为95.2%和95.0%。FLT的平均（+/- SD）SUV（7.0 +/- 3.3）显著低于FDG（9.4 +/- 6.3 p < 0.05）。非肠道肿瘤的平均FLT SUV和FDG SUV高于肠道肿瘤，尽管差异无统计学意义。低分化肿瘤的平均（+/- SD）FLT SUV（8.5 +/- 3.5）显著高于高分化和中等分化肿瘤（5.3 +/- 2.1; p < 0.04）。低分化肿瘤的平均FDG SUV高于高分化和中等分化肿瘤，尽管差异无统计学意义。Ki-67指数与FLT SUV或FDG SUV均无显著相关性。FLT PET对胃癌的敏感性与FDG PET相当，但胃癌的FLT摄取明显低于FDG。
We prospectively investigated the feasibility of 3'-deoxy-3'-F-18-fluorothymidine (FLT) positron emission tomography (PET) for the detection of gastric cancer, in comparison with 2-deoxy-2-F-18-fluoro-d-glucose (FDG) PET, and determined the degree of correlation between the two radiotracers and proliferative activity as indicated by Ki-67 index.A total of 21 patients with newly diagnosed advanced gastric cancer were examined with FLT PET and FDG PET. Tumour lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated.For detection of advanced gastric cancer, the sensitivities of FLT PET and FDG PET were 95.2% and 95.0%, respectively. The mean (+/- SD) SUV for FLT (7.0 +/- 3.3) was significantly lower than that for FDG (9.4 +/- 6.3 p < 0.05). The mean FLT SUV and FDG SUV in nonintestinal tumours were higher than in intestinal tumours, although the difference was not statistically significant. The mean (+/- SD) FLT SUV in poorly differentiated tumours (8.5 +/- 3.5) was significantly higher than that in well and moderately differentiated tumours (5.3 +/- 2.1; p < 0.04). The mean FDG SUV in poorly differentiated tumours was higher than in well and moderately differentiated tumours, although the difference was not statistically significant. There was no significant correlation between Ki-67 index and either FLT SUV or FDG SUV.FLT PET showed as high a sensitivity as FDG PET for the detection of gastric cancer, although uptake of FLT in gastric cancer was significantly lower than that of FDG.