Comparative epidemiology of epilepsy in Pakistan and Turkey: Population-based studies using identical protocols
Comparative epidemiology of epilepsy in Pakistan and Turkey: Population-based studies using identical protocols
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DOI：
10.1111/j.1528-1157.1997.tb01242.x
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发表时间：
1997-06-01
期刊：
影响因子：
5.6
通讯作者：
Hasan, KZ
中科院分区：
文献类型：
--
作者：
Aziz, H;Guvener, A;Hasan, KZ
目的：确定巴基斯坦和土耳其癫痫的患病率、人口学、现象学、癫痫发作分类、假定病因、治疗状况和选定的社会人类学方面。方法：在巴基斯坦和土耳其设计了一项基于人群的跨文化癫痫比较研究，同时进行相同的方案。设计的基本特征是未选择的人群，参考他们以前的医疗接触，并使用标准化的国际社区癫痫研究小组(ICBERG)方案来评估跨文化差异。结果：总共研究了巴基斯坦的24,130人和土耳其的11,497人(城市和农村，所有年龄和性别)。巴基斯坦的癫痫粗患病率为9.98‰，土耳其为7.0‰(巴基斯坦农村地区为14.8‰，城市地区为7.4‰；土耳其农村地区为8.8‰，城市地区为4.5‰)。在这两个国家，农村地区的癫痫发病率是城市地区的两倍。巴基斯坦和土耳其癫痫的平均发病年龄分别为13.3岁和12.9岁。两国癫痫发作类型的总体频率相似，没有城乡差异。巴基斯坦和土耳其的频率分布分别为：全面性强直阵挛，80.5和65.4%；单纯性部分性阵挛，5%和7.4%；复杂部分性阵挛，5%和12.3%；全面性缺失，0.8%和4.9%；强直性和失调性，分别为5.8%和3.7%；肌阵挛，5.8%和1.2%。在巴基斯坦和土耳其，38.4%的病例和35.7%的病例可能是癫痫的推定原因。在巴基斯坦，只有3%的患者，但在土耳其，71%的患者认为他们的疾病是由超自然原因造成的。治疗状况非常差。在巴基斯坦，在调查时，27.5%的城市地区癫痫患者和1.9%的农村地区癫痫患者正在接受抗癫痫药物治疗。在土耳其，30%的患者服用抗癫痫药物(农村地区略高)。结论：巴基斯坦癫痫的患病率略高于土耳其；年龄和性别分布上的一些边际差异，在统计学上没有显著差异。这一结果与厄瓜多尔的结果相当，后者使用了相同的流行病学方案。
Purpose: To determine comparative prevalence rates, demographics, phenomenology, seizure classification, presumptive etiology, treatment status, and selected socioanthropological aspects of epilepsy in Pakistan and Turkey.Methods: A population-based, cross-cultural comparative study of epilepsy was designed with identical protocols to be performed simultaneously in Pakistan and Turkey. The essential feature of the design was an unselected population, with reference to their previous medical contact, and use of standardized International Community-Based Epilepsy Research Group (ICBERG) protocols to assess cross-cultural differences.Results: In all, 24,130 persons in Pakistan and 11,497 persons in Turkey (both urban and rural, of all ages and both sexes) were studied. The crude prevalence rate of epilepsy was 9.98 in 1,000 in Pakistan and 7.0 in 1,000 in Turkey (14.8 in 1.000 in rural and 7.4 in 1,000 in urban areas of Pakistan; 8.8 in 1,000 in rural and 4.5 in 1,000 in urban areas of Turkey). In both countries, epilepsy was twice as prevalent in rural areas than in urban areas. Mean age of onset of epilepsy was 13.3 years in Pakistan and 12.9 years in Turkey. Overall frequency of seizure types was similar in both countries, with no urban/rural differences. The frequency distribution in Pakistan and Turkey, respectively, was as follows: generalized tonic-clonic, 80.5 and 65.4%; simple partial, 5 and 7.4%; complex partial, 5 and 12.3%; generalized absence, 0.8 and 4.9%; tonic and atonic, 5.8 and 3.7% each; and myoclonic, 5.8 and 1.2%. A putative cause for the epilepsy could be attributed in 38.4% of cases in Pakistan and 35.7% of cases in Turkey. Only 3% of patients in Pakistan, but 71% of patients in Turkey, believed that their illness was due to supernatural causes. The treatment status was very poor. In Pakistan, 27.5% of people with epilepsy in urban areas and 1.9% of people with epilepsy in rural areas were receiving antiepileptic drugs (AEDs) at the time of the survey. In, Turkey 30% of patients were receiving AEDs (marginally higher in rural areas).Conclusions: The prevalence of epilepsy is slightly higher in Pakistan than in Turkey; some marginal differences in age and sex distribution, are not statistically significant. The results are comparable to those in Ecuador, where the same epidemiologic protocol was used.