Artificial scaffolding materials for tissue extracellular matrix repair
Artificial scaffolding materials for tissue extracellular matrix repair
复制标题
用于组织细胞外基质修复的人工支架材料
DOI：
10.1097/00001433-199612000-00013
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
C. Rivard
中科院分区：
文献类型：
--
作者：
C. Chaput;A. Selmani;C. Rivard
骨科组织工程正在迅速发展，导致细胞和分子生物学，生物材料，植入物和可吸收聚合物工程以及专业生物技术领域之间的重要跨学科合作。使用由可吸收有机或无机材料制成的分级多孔骨诱导和骨传导材料探索骨形成。软骨、韧带和肌腱再生的重点是使用分离的软骨细胞接种或封装在人工细胞外基质中，三维细胞培养，组织等效培养和再移植。最佳生物可吸收支架材料的开发是组织工程的关键步骤，必须针对目标组织进行定制：生物相容性、多孔性、成形、三维、组织诱导、引导或传导材料和结构必须具有足够的表面化学、物理和电学性质;最佳组成、微观结构、孔隙率和建筑特征;以及相容的生物降解和消除速率。结合支架功能和受控递送动作也被视为改善组织再生过程的管理。
Tissue engineering of orthopedic tissues is expanding rapidly, leading to important interdisciplinary collaborations between cellular and molecular biology, biomaterials, implants, and engineering of absorbable polymers as well as specialized biotechnologic fields. Bone formation is explored using hierarchical porous osteoinducing and osteconducting materials made of resorbable organic or inorganic materials. Cartilage, ligament, and tendon regeneration is focusing on the use of isolated chondrocytic cells seeded or encapsulated within artificial extracellular matrices, three-dimensional cell cultures, and tissue-equivalent culture and retransplantation. The development of optimal biabsorbable scaffolding materials, a key step for the engineering of tissues, must be customized to the targeted tissue: biocompatible, porous, shaped, three-dimensional, tissue-inducing,-guiding, or-conducting materials and structures must have adequate surface chemical, physical, and electrical properties; optimal compositional, microstructural, porosimetric, and architectural characteristics; and compatible biodegradation and elimination rates. Combining scaffolding functions and controlled delivering actions is also viewed as improving the management of tissue regeneration processes.