Identification of isoforms and RH mapping of canine KIT
Identification of isoforms and RH mapping of canine KIT
复制标题
犬 KIT 亚型的鉴定和 RH 作图
DOI：
10.1159/000075759
复制
发表时间：
2004
影响因子：
1.7
通讯作者：
K. Murphy
中科院分区：
文献类型：
--
作者：
K. Tsai;R. Guyon;K. Murphy
原癌基因c-kit(Kit)编码一种酪氨酸激酶受体，该基因的突变会导致几种哺乳动物疾病，包括癌症和一种与色素沉着相关的遗传性耳聋。我们的实验室对一种遗传性耳聋感兴趣，这种耳聋与色素沉着异常有关，在达尔马提亚人中很常见。因此，KIT被分析为该品种耳聋的候选基因。除了我们对耳聋的兴趣外，我们还参与了犬类基因组中的基因定位。本文报道了犬C-KIT的两种亚型的鉴定以及KIT与CFA13的辐射杂交定位。
The proto-oncogene, c-kit (KIT), encodes a tyrosine kinase receptor, and mutations in this gene are causative for several mammalian diseases, including cancer and a form of pigmentation-associated hereditary deafness. Our laboratories are interested in a form of hereditary deafness that is associated with abnormalities in pigmentation and is common in the Dalmatian. Thus, KIT is being analyzed as a candidate gene for deafness in this breed. In addition to our interest in deafness, we are involved in mapping gene loci in the canine genome. Reported here is the identification of two isoforms of canine C-kit and radiation hybrid mapping of KIT to CFA13.
家鼠显性白斑 (W) 基因座的多效性分析：十个新 W 等位基因的描述。
影响因子：
3.3
作者：
Geissler,EN;McFarland,EC;Russell,ES
通讯作者：
Russell,ES
影响因子：
2.6
作者：
London, CA;Galli, SJ;Geissler, EN
通讯作者：
Geissler, EN