Inverse psoriasis treated with ustekinumab.
Inverse psoriasis treated with ustekinumab.
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DOI：
10.1136/bcr-2016-215019
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发表时间：
2016-05-24
期刊：
影响因子：
0.9
通讯作者：
Moreira, Ana Isabel
中科院分区：
文献类型：
--
作者：
Campos, Manuel Antonio;Varela, Paulo;Moreira, Ana Isabel
反牛皮癣的特征是涉及弯曲的皮肤皱襞。这种形式的牛皮癣具有独特的临床和治疗特征。本报告涉及一名在我们部门观察的 48 岁白人男性病例，经临床和活检证实诊断为反牛皮癣。两年来，该患者接受了皮质类固醇、维生素 D 类似物和甲氨蝶呤的不同组合治疗，但没有令人满意的反应。鉴于缺乏临床反应和合并症，潜伏性结核病被排除，我们开始使用优特克单抗治疗。我们选择这种生物制剂是因为患者是一名长途卡车司机，拒绝自我注射的可能性。该患者接受了 3 次乌司奴单抗注射，瘙痒、红斑病变和生活质量得到显着改善。
Inverse psoriasis is characterised by the involvement of flexural skin folds. This form of psoriasis has distinct clinical and therapeutic features. This report refers to the case of a 48-year-old Caucasian man who was observed in our department, with a clinically and biopsy proven diagnosis of inverse psoriasis. For 2 years, the patient was treated with different combinations of corticosteroids, vitamin D analogues and methotrexate, with no satisfactory response. Given the lack of a clinical response and comorbidities, latent tuberculosis was excluded, and we started treatment with ustekinumab. We chose this biological agent because the patient was a long-distance truck driver and refused the possibility of autoinjections. The patient underwent three ustekinumab injections, which resulted in significant improvement of pruritus, erythaematous lesions and quality of life.