Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.
Applications of Ring Closing Metathesis. Total Synthesis of (±)-Pseudotabersonine.
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DOI：
10.1016/j.tet.2015.04.082
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发表时间：
2015-09-30
期刊：
影响因子：
2.1
通讯作者：
Martin SF
中科院分区：
文献类型：
--
作者：
Cheng B;Sunderhaus JD;Martin SF
开发了一种新的Aspidosperma生物碱家族的合成方法，并将其应用于(±)-伪tabersonine的简明全合成，该合成过程经11步完成。关键的转变包括Mannich式多组分组装过程的逐步变体、双环闭合复分解序列和一锅脱保护/环化反应。
A novel approach to the Aspidosperma family of alkaloids was developed and applied to a concise total synthesis of (±)-pseudotabersonine that was accomplished in 11 steps. Key transformations include a stepwise variant of a Mannich-like multicomponent assembly process, a double ring-closing metathesis sequence, and a one-pot deprotection/cyclization reaction.