Kinetics of formation of neutralizing antibodies against vaccinia virus following re-vaccination
Kinetics of formation of neutralizing antibodies against vaccinia virus following re-vaccination
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DOI：
10.1016/s0264-410x(98)00197-2
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发表时间：
1999-01-21
期刊：
影响因子：
5.5
通讯作者：
Katz, E
中科院分区：
文献类型：
--
作者：
Stienlauf, S;Shoresh, M;Katz, E
接种健康成人志愿者的牛痘免疫球蛋白（VIG）是天花疫苗接种后严重并发症患者的首选治疗方法。本研究旨在确定疫苗接种后获得最高中和抗体滴度的时间间隔。99名18岁的士兵，在出生时接种了牛痘病毒，参加了这项研究，其中87人在重新接种疫苗之前有可检测到的牛痘病毒抗体。其初始平均中和抗体滴度（NT50）为27。免疫后14 d，抗体滴度达152，21、30、45和60 d分别降至136、119、110和87。在研究开始时，在没有可检测到的抗体的疫苗接种者中诱导的牛痘抗体滴度显著较低，并且在再接种后观察到的滴度分别为：在14、21、30、45和60 d分别为62、56、66、38和34。在另一项研究中，65名志愿者在出生时接种疫苗，并在8岁时再次接种疫苗。14天后，他们的NT50高于出生时接种疫苗的人。结果表明，再免后14d采血是制备VIG的最佳时间。(C)1998爱思唯尔科技有限公司版权所有。
Administration of vaccinia immune globulin (VIG), derived from vaccinated healthy adult volunteers, is the treatment-of-choice for patients suffering from severe complications following smallpox vaccination. The present study was aimed to determine the time interval after vaccination, at which the highest titer of neutralizing antibodies is obtained. Ninety-nine 18-year-old soldiers, immunized with vaccinia virus at birth, participated in the study, 87 of whom had detectable antibodies against vaccinia virus prior to re-vaccination. Their initial average neutralizing antibodies titer (NT50) was 27. Fourteen days after re-vaccination the titer reached 152 and then dropped to 136, 119, 110 and 87 at 21, 30, 45 and 60 d, respectively. The titers of vaccinia antibodies induced in vaccinees without detectable antibodies at the start of the study, were significantly lower and the titers observed after re-vaccination were: 62, 56, 66, 38 and 34, at 14, 21, 30, 45 and 60 d, respectively. In an additional study, 65 Volunteers vaccinated at birth and again at the age of 8 years old were re-vaccinated. Fourteen days later their NT50 was higher than those vaccinated only at birth. It can be concluded that bleeding of vaccinees 14 d following re-vaccination is the preferable time for the preparation of VIG. (C) 1998 Elsevier Science Ltd. All rights reserved.