Exploring the origins of asthma: Lessons from twin studies.
Exploring the origins of asthma: Lessons from twin studies.
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DOI：
10.3402/ecrj.v1.25535
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发表时间：
2014
影响因子：
1.9
通讯作者：
Thomsen SF
中科院分区：
文献类型：
--
作者：
Thomsen SF
本文探讨了双生子研究，特别是那些来自丹麦双生子登记处的研究，对哮喘病因学的理解的贡献。首先，它是探讨如何双胞胎研究建立了遗传和环境因素的贡献，在哮喘的易感性的变化，并在几个方面的变化的疾病的临床表现，如其发病年龄，其发病学，其中间表型，其与其他特应性疾病。接下来，它是探讨如何双胞胎研究证实了解释哮喘的患病率最近增加的理论，最后，这些如何符合现代其他常见慢性病的流行病学趋势的解释。
This thesis explores the contribution of twin studies, particularly those studies originating from the Danish Twin Registry, to the understanding of the aetiology of asthma. First, it is explored how twin studies have established the contribution of genetic and environmental factors to the variation in the susceptibility to asthma, and to the variation in several aspects of the clinical expression of the disease such as its age at onset, its symptomatology, its intermediate phenotypes, and its relationship with other atopic diseases. Next, it is explored how twin studies have corroborated theories explaining asthma's recent increase in prevalence, and last, how these fit with the explanations of the epidemiological trends in other common chronic diseases of modernity.