Human amygdala responses during presentation of happy and neutral faces: Correlations with state anxiety
Human amygdala responses during presentation of happy and neutral faces: Correlations with state anxiety
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DOI：
10.1016/j.biopsych.2004.01.007
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发表时间：
2004-05-01
影响因子：
10.6
通讯作者：
Whalen, PJ
中科院分区：
文献类型：
--
作者：
Somerville, LH;Kim, H;Whalen, PJ
背景以往的功能成像研究表明，杏仁核的反应，快乐的面部表情都包括在实验背景下的负价的主要比较表达式的介绍。本研究在没有初级负价比较表情的实验范式中评估了杏仁核对快乐和中性面部表情的反应。（8名女性）在两次功能性磁共振成像扫描期间，在基线固定条件下观察16秒的交替快乐和中性面孔块。在腹侧杏仁核内，观察到快乐与中性信号变化与状态焦虑之间存在负相关，与这种效应相关的大部分变异性可以用状态焦虑和信号变化之间的正相关来解释，中立的面孔。结论。杏仁核对面部表情的反应的解释将受到以下因素的影响：考虑每个组成条件在更大减法发现中的贡献，以及1）它们在杏仁核复合体中的空间位置; 2）观察它们的实验背景。在这里，观察到的状态焦虑和腹侧杏仁核反应的快乐与中性的面孔之间的关系被解释为中性的面孔。
Background. Previous functional imaging studies demonstrating amygdala response to happy facial expressions have all included the presentation of negatively valenced primary comparison expressions within the experimental context. This study assessed amygdala response to happy and neutral facial expressions in an experimental paradigm devoid of primary negatively valenced comparison expressions.Methods: Sixteen human subjects (eight female) viewed 16-sec blocks of alternating happy and neutral faces interleaved with a baseline fixation condition during two functional magnetic resonance imaging scans.Results: Within the ventral amygdala, a negative correlation between happy versus neutral signal changes and state anxiety was observed, The majority of the variability associated with this effect was explained by a positive relationship between state anxiety and signal change to neutral faces.Conclusions. Interpretation of amygdala responses to facial expressions of emotion will be influenced by considering the contribution of each constituent condition within a greater subtractive finding, as well as 1) their spatial location within the amygdaloid complex; and 2) the experimental context in which they were observed. Here, an observed relationship between state anxiety and ventral amygdala response to happy versus neutral faces was explained by response to neutral faces.