Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge
Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge
复制标题
文冠果叶子中的生物活性酚作为潜在的神经炎症抑制剂
DOI：
10.1016/j.bmcl.2016.08.094
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发表时间：
2016-10-15
影响因子：
2.7
通讯作者：
Meng, Dali
中科院分区：
文献类型：
--
作者：
Li, Ning;Wang, Ying;Meng, Dali
文冠果是一种药用植物，也是中国用于生产食用油和生物燃料的宝贵经济作物。在我们前期的研究中，系统地获得了文冠果不同部位的植物化学和生物活性特征。在这里，我们描述了文冠果叶子中的有效酚类，它可以作为天然的神经炎症抑制剂。通过色谱、光谱分析等方法，将23种化合物定性为文冠果叶中的酚类化合物。其中，黄酮类槲皮素3-O-β-D-吡喃葡萄糖苷（IC50 13.39 +/- 1.27 μM）、儿茶素（IC50 9.52 +/- 2.18 μM）和苯丙素类丁香树脂醇-4-O-β-D-吡喃葡萄糖苷（IC50 3.08 +/- 1.77 μM），在LPS诱导的BV2细胞中，4-O-β-D-吡喃葡萄糖基-反式-对香豆酸（IC50 9.08 +/- 1.23 μM）对NO产生的抑制作用比阳性对照米诺环素（IC50 37.04 +/- 2.09 μM）强得多。 (C) 2016 年由爱思唯尔有限公司出版。
Xanthoceras sorbifolia Bunge is a medicinal plant and also a valuable cash crop used for production of edible oil and biofuels in China. In our previous research, systematical phytochemical and bioactive profiles of different parts from X. sorbifolia have been obtained. Here we describe the effective phenols from the leaves of X. sorbifolia, which could function as natural neuroinflammation inhibitors. As a result, 23 compounds were characterized as the phenols from the leaves of X. sorbifolia by means of chromatographical methods and spectroscopic analysis. Among them, flavonoids quercetin3-O-beta-D-glucopyarnoside (IC50 13.39 +/- 1.27 mu M), catechin (IC50 9.52 +/- 2.18 mu M), and phenylpropanoids syringaresinol-4-O-beta-D-glucopyranoside (IC50 3.08 +/- 1.77 mu M), 4-O-beta-D-glucopyranosyl-trans-p-coumaric acid (IC50 9.08 +/- 1.23 mu M) exhibited much stronger inhibiting effect on NO production than that of the positive control minocycline (IC50 37.04 +/- 2.09 mu M) in LPS-induced BV2 cells. (C) 2016 Published by Elsevier Ltd.