A Moldable Nanocomposite Hydrogel Composed of a Mussel-Inspired Polymer and a Nanosilicate as a Fit-to-Shape Tissue Sealant.
A Moldable Nanocomposite Hydrogel Composed of a Mussel-Inspired Polymer and a Nanosilicate as a Fit-to-Shape Tissue Sealant.
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DOI：
10.1002/anie.201700628
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发表时间：
2017-04-03
期刊：
影响因子：
--
通讯作者：
Lee BP
中科院分区：
文献类型：
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作者：
Liu Y;Meng H;Qian Z;Fan N;Choi W;Zhao F;Lee BP
设计生物粘合剂以粘合并符合组织表面的复杂轮廓仍然是一个挑战。我们通过将多巴胺改性的聚乙二醇和纳米硅酸盐合成锂皂石相结合，开发了一种新型可模压纳米复合水凝胶，且不使用细胞毒性氧化剂。通过儿茶酚部分的缓慢自氧化和交联，水凝胶从多巴胺-锂皂石界面相互作用形成的可逆交联网络转变为共价交联网络。最初，水凝胶可以重塑为不同的形状，可以从大应变变形中恢复，并且可以通过注射器注射以粘附到组织表面的凸形轮廓。随着时间的推移，水凝胶凝固以形成新的形状并密封组织上的缺陷。这种贴合形状的密封剂具有密封具有非平坦几何形状的组织的潜力，例如缝合吻合。通过将贻贝启发的聚合物和纳米硅酸盐相结合，开发了一种新型可模压纳米复合水凝胶。水凝胶从主要是物理交联的网络转变为共价交联的网络。在这个动态过程中，水凝胶最初是可重塑和可注射的，并且可以粘附到具有凸轮廓的组织上。随着时间的推移，水凝胶被固定成新的形状，并起到贴合形状密封剂的作用。
Engineering bioadhesives to bind and conform to the complex contour of tissue surfaces remains a challenge. We developed a novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) and nano-silicate, Laponite, without using cytotoxic oxidants. The hydrogel transitioned from a reversibly crosslinked network formed from dopamine-Laponite interfacial interactions to a covalently crosslinked network through the slow autoxidation and crosslinking of catechol moieties. Initially, the hydrogel can be remolded to different shapes, can recover from large strain deformation, and can be injected through a syringe to adhere to the convex contour of a tissue surface. With time, the hydrogel solidified to adopt the new shape and sealed defects on the tissue. This fit-to-shape sealant has potential in sealing tissues with non-flat geometries, such as a sutured anastomosis. A novel moldable nanocomposite hydrogel was developed by combining a mussel-inspired polymer and nano-silicate. The hydrogel transitioned from a predominantly physically crosslinked network to a covalently crosslinked one. During this dynamic process, the hydrogel was initially remoldable and injectable, and can adhere to tissue with a convex contour. With time, the hydrogel was fixed in its new shape and functioned as a fit-to-shape sealant.