Serum fetuin-B is positively associated with intrahepatic triglyceride content and increases the risk of insulin resistance in obese Chinese adults: A cross-sectional study
Serum fetuin-B is positively associated with intrahepatic triglyceride content and increases the risk of insulin resistance in obese Chinese adults: A cross-sectional study
复制标题
DOI：
10.1111/1753-0407.12632
复制
发表时间：
2018-07-01
影响因子：
4.5
通讯作者：
Li, Xuejun
中科院分区：
文献类型：
--
作者：
Wang, Dongmei;Liu, Yijie;Li, Xuejun
背景：胎球蛋白B损害肌管和肝细胞中的胰岛素作用，并导致小鼠葡萄糖耐受不良。本研究探讨血清胎球蛋白B和肝内甘油三酯（IHTG）含量之间的相关性，和胎球蛋白B和胰岛素抵抗的风险之间的关联在一般成年population.Methods：一个横断面研究的1318肥胖成年人进行血清胎球蛋白B检测和肝脏超声检查在厦门，中国进行。采用磁共振波谱法测定428例受试者的IHTG含量。血清胎球蛋白-B浓度和IHTC含量最高的人群非酒精性脂肪肝患病率显著较高（三分位数3）中的受试者比三分位数1和2中的受试者（分别为62.6% vs 60.7%和54.3%[P = 0.032]，以及分别为15.3% vs 12.8%和12.7%[P = 0.049]）。血清胎球蛋白B三分位数的增加与空腹胰岛素浓度的增加有显著相关性（三分位数1、2和3的平均值[+/- SD]分别为11.9 +/- 6.8、12.7 +/- 7.6和13.3 +/- 6.4 mIU/L; P = 0.006）和胰岛素抵抗患病率（第1、2和3分位数分别为54.4%、58.9%和64.5%; P = 0.010）。线性回归分析显示，IHTG含量与血清胎球蛋白B呈独立正相关（回归系数0.015; P = 0.045）。调整潜在的混杂因素，血清胎球蛋白-B是独立相关的胰岛素抵抗的风险增加，与调整后的比值比每标准差增加胎球蛋白-B的1.14（95%置信区间1.01-1.30; P = 0.031）。结论：结果表明，胎球蛋白-B的作用，连接肝脏脂肪积累的胰岛素抵抗在人类。
Background: Fetuin-B impairs insulin action in myotubes and hepatocytes and causes glucose intolerance in mice. This study explored the correlation between serum fetuin-B and intrahepatic triglyceride (IHTG) content, and the association between fetuin-B and the risk of insulin resistance in the general adult population.Methods: A cross-sectional study of 1318 obese adults who underwent serum fetuin-B testing and hepatic ultrasonography was conducted in Xiamen, China. The IHTG content was determined in 428 subjects by magnetic resonance spectroscopy.Results: Non-alcoholic fatty liver disease prevalence was significantly higher in those with the highest serum fetuin-B concentrations and the highest IHTC content (Tertile 3) than in subjects in Tertiles 1 and 2 (62.6% vs 60.7% and 54.3%, respectively [P = 0.032], and 15.3% vs 12.8% and 12.7%, respectively [P = 0.049]). There was a significant association between increasing serum fetuin-B tertiles and both increasing fasting insulin concentrations (mean [+/- SD] 11.9 +/- 6.8, 12.7 +/- 7.6, and 13.3 +/- 6.4 mIU/L in Tertiles 1, 2 and 3, respectively; P = 0.006) and prevalence of insulin resistance (54.4%, 58.9%, and 64.5% in Tertiles 1, 2 and 3, respectively; P = 0.010). In linear regression analysis, IHTG content was independently and positively correlated with serum fetuin-B (regression coefficient 0.015; P = 0.045). With adjustment for potential confounders, serum fetuin-B was independently associated with increased risk of insulin resistance, with an adjusted odds ratio per standard deviation increase in fetuin-B of 1.14 (95% confidence interval 1.01-1.30; P = 0.031).Conclusions: The results demonstrate the role of fetuin-B linking liver fat accumulation to insulin resistance in humans.