Principles of High-Intensity Focused Ultrasound
Principles of High-Intensity Focused Ultrasound
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DOI：
10.1007/978-1-4419-1469-9_5
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发表时间：
2012-01-01
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影响因子：
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通讯作者：
ter Haar, Gail
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文献类型：
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作者：
ter Haar, Gail
虽然其用于治疗目的早于诊断应用几十年，但超声最广为人知的是其成像能力。超声波（US）通过组织可能导致可逆或不可逆的生物学变化。这些效应的生物学意义在很大程度上取决于超声波束中的能量和暴露的目标。在诊断水平上，任何变化在很大程度上都被认为是生物学上无意义的。对于治疗性超声，有意地寻求有益的细胞或功能效应，无论这些效应是在细胞膜水平（例如，渗透性的瞬时变化以促进药物递送）或不太微妙的效应，例如在高强度聚焦超声（HIFU;该技术有时也称为FUS）中实现立即热坏死所需的局部温度升高。
Although its use for therapeutic purposes predates diagnostic applications by several decades, ultrasound is most widely known for its imaging capabilities. The passage of ultrasound (US) through tissue can lead to biological changes that may be reversible or irreversible. The biological significance of these effects depends to a large extent on the energy in the ultrasound beam and the goal of the exposure. At diagnostic levels, any changes are largely believed to be biologically insignificant. For therapeutic ultrasound, beneficial cellular or functional effects are deliberately sought, whether these are at the cell membrane level (e.g., transient changes in permeability to facilitate drug delivery) or less subtle effects such as the localised temperatures rises that are required to achieve immediate thermal necrosis in high intensity focused ultrasound (HIFU; this technique is sometimes also referred to as FUS).