On cochlear impedances and the miscomputation of power gain.
On cochlear impedances and the miscomputation of power gain.
复制标题
关于耳蜗阻抗和功率增益的错误计算。
DOI：
10.1007/s10162-011-0287-y
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
GuinanJr,JohnJ
中科院分区：
文献类型：
--
作者：
Shera,ChristopherA;Olson,ElizabethS;GuinanJr,JohnJ
在他们的文章“Measurement of cochlear power gain in the sensitive gerbil ear”中，Ren等人（Nat Commun 2：216，2011）声称提供了“在敏感的活体耳蜗中功率放大的第一个直接实验证据”。虽然我们认识到实验的技术挑战并欣赏数据的美丽，但作者对测量结果的分析和解释是无效的。我们回顾阻抗的概念（即，压力与速度之比），因为它适用于耳蜗力学，并表明Ren等人错误地将基底膜和镫骨附近的阻抗等同于无限均匀流体管的阻抗特性。由于这一错误，Ren et al.的测量和分析没有提供耳蜗中功率放大的证据。然而，其他人先前已经提供了关于功率放大的令人信服的证据。
In their article, “Measurement of cochlear power gain in the sensitive gerbil ear,” Ren et al. (Nat Commun 2:216, 2011) claim to provide “the first direct experimental evidence of power amplification in the sensitive living cochlea.” While we recognize the technical challenges of the experiments and appreciate the beauty of the data, the authors’ analysis and interpretation of the measurements are invalid. We review the concept of impedance (i.e., the ratio of pressure to velocity) as it applies to cochlear mechanics and show that Ren et al. mistakenly equate the impedances near the basilar membrane and stapes with the impedance characteristic of an infinite, uniform tube of fluid. As a consequence of this error, Ren et al.’s measurements and analysis provide no evidence for power amplification in the cochlea. Compelling evidence for power amplification has, however, been previously provided by others.