Monitoring alveolar epithelial function in acute lung injury.
Monitoring alveolar epithelial function in acute lung injury.
复制标题
监测急性肺损伤中的肺泡上皮功能。
DOI：
10.1023/a:1011407820548
复制
发表时间：
2000
影响因子：
2.2
通讯作者：
Hastings,RH
中科院分区：
文献类型：
--
作者：
Hastings,RH
Objective.Identification of humoral markers of acute lung injury may lead to insights into pathologic mechanisms. In addition, specific markers may be useful for predicting development of acute respiratory distress syndrome (ARDS) or for assessing prognosis. Ultimately, studies of lung injury markers may help define interventions that prevent or moderate ARDS. The alveolar epithelium is important both for the integrity of the blood-gas barrier and for repair of the barrier after lung injury. This article reviews markers that derive from or relate to the alveolar epithelium and that might be used for monitoring alveolar epithelial function in acute lung injury. Surfactant apoproteins may be important markers of injury or for prognosis. Levels of surfactant apoprotein A (SP-A) fall 50–75% in patients with severe lung injury compared to normal patients. Serum levels of SP-A in patients dying of acute respiratory distress syndrome are double serum levels of survivors.
