Convergence of non-communicable diseases and tuberculosis: a two-way street?
Convergence of non-communicable diseases and tuberculosis: a two-way street?
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DOI：
10.5588/ijtld.18.0045
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发表时间：
2018-11-01
影响因子：
4
通讯作者：
Kornfeld, H.
中科院分区：
文献类型：
--
作者：
Magee, M. J.;Salindri, A. D.;Kornfeld, H.
结核病（TB）与非传染性疾病（NCDs）的交叉，包括糖尿病（DM）、慢性肺病（CLD）和心血管疾病（CVD），已成为一个关键的临床和公共卫生挑战。在低收入和中等收入国家，迅速扩大的非传染性疾病流行病威胁着结核病的控制，在这些国家，结核病的预防和治疗仍然是一个巨大的负担。然而，迄今为止，结核病可能对非传染性疾病风险和严重程度产生不利影响的概念尚未得到很好的探讨。本文综述了与活动性结核病期间和之后DM、CLD和CVD进展相关的生物医学假设、动物模型研究结果以及新出现的流行病学数据。我们的结论是，有足够的经验证据证明更重视结核病和非传染性疾病之间的疾病相互作用的研究是合理的。
The intersection of tuberculosis (TB) with non-communicable diseases (NCDs), including diabetes mellitus (DM), chronic lung disease (CLD), and cardiovascular disease (CVD), has emerged as a critical clinical and public health challenge. Rapidly expanding NCD epidemics threaten TB control in low- and middle-income countries, where the prevention and treatment of TB disease remain a great burden. However, to date, the notion that TB may adversely impact NCD risk and severity has not been well explored. This review summarizes biomedical hypotheses, findings from animal models, and emerging epidemiologic data related to the progression of DM, CLD and CVD during and after active TB disease. We conclude that there is sufficient empirical evidence to justify a greater research emphasis on the syndemic interaction between TB and NCD.