Trends in the incidence of childhood-onset diabetes in Europe 1989-1998
Trends in the incidence of childhood-onset diabetes in Europe 1989-1998
复制标题
DOI：
10.1007/pl00002950
复制
发表时间：
2001-10-01
期刊：
影响因子：
8.2
通讯作者：
Patterson, CC
中科院分区：
文献类型：
--
作者：
Green, A;Patterson, CC
目的/假说。目的研究欧洲儿童发病（1型）胰岛素依赖型糖尿病的流行病学。1988年，EURODIAB合作小组建立了所有15岁以下诊断为1型糖尿病的儿童的前瞻性、地理定义的登记册。本报告以1989-1998年期间36个中心登记的24423名儿童为基础，这些儿童完全参与了调查，代表了人口覆盖约2000万儿童的大多数欧洲国家。确定的多个来源被用来验证确定的水平。使用泊松回归分析了这段时间内I型糖尿病发病率的趋势，结果来自9个地区的36个中心。1型糖尿病的标准化年平均发病率在各中心之间的差异超过10倍。总体而言，年发病率增加3.2% (95% -CI: 2.7%, 3.7%)， 0-4岁年龄组儿童最高4.8%(3.8%,5.9%)，10-14岁年龄组儿童最低2.1%（1.4%,2.8%）。然而，在0-4岁、5-9岁和10-14岁这三个年龄组中，I型糖尿病的绝对增长情况大致相似。中欧和东欧的增幅最大，而撒丁岛和北欧（芬兰除外）则没有增加的迹象。所有年龄组在夏季发病的病例相对较少，特别是10-14岁年龄组。已证实欧洲境内的发病率范围非常大。发病率普遍上升，但在某些区域比其他区域更为明显。即使在最年轻的年龄组中，发病时的季节性也很明显。
Aims/hypothesis. To study the epidemiology of childhood-onset (Type 1) insulin-dependent diabetes mellitus in Europe., the EURODIAB collaborative group in 1988 established prospective, geographically-defined registers of all children diagnosed with Type I diabetes under 15 years of age. This report is based on 24423 children, registered by 36 centres, with complete participation during the period 1989-1998 and representing most European countries with a population coverage of approximately 20 million children.Methods. Multiple sources of ascertainment were used to validate the level of ascertainment. Trends in Type I diabetes incidence during the period were analysed using Poisson regression with the results from the 36 centres pooled into nine regions.Results. The standardised average annual incidence rate of Type I diabetes varied more than tenfold between centres. Overall, the annual increase in incidence was 3.2 % (95 % -CI: 2.7 %, 3.7 %), being highest for children in the 0-4-year age-group 4.8 % (3.8 %, 5.9 %) and lowest for children in the 10-14-year age group 2.1 % (1.4 %, 2.8 %). However, the absolute increases in Type I diabetes were roughly similar in the three age-groups of 0-4, 5-9 and 10-14 years. Central Eastern Europe showed the highest increase whereas Sardinia and Northern Europe (except Finland) showed no evidence of an increase. For all age-groups relatively fewer cases had disease onset during the summer months, especially the 10-14-year age-group.Conclusion/interpretation. The extremely large range of incidence rates within Europe has been confirmed. The incidence rate is generally increasing but is more pronounced in some regions than in others. Seasonality at disease onset is apparent even in the youngest age-group.