Homoflavonoids from Ophioglossum petiolatum
Homoflavonoids from Ophioglossum petiolatum
复制标题
DOI：
10.1021/np0401819
复制
发表时间：
2005-03-01
影响因子：
5.1
通讯作者：
Chang, YY
中科院分区：
文献类型：
--
作者：
Lin, YL;Shen, CC;Chang, YY
从麦冬中分离得到6个高黄酮类化合物，分别为麦冬木素(1)、麦冬木素7-O-β-D-吡喃葡萄糖苷(2)、麦草木酚(3)、麦草异黄酮醇戊烯基醚(4)、麦草木龙醇4‘-O-β-D-葡萄糖苷(5)和7-O-β-D-葡萄糖苷(6)，以及5个已知化合物：槲皮素、木犀草素、山奈酚、3，5，7，3’，4‘-五羟基-8-戊基黄酮和槲皮素3-O-甲基醚。通过光谱分析和化学证据确证了它们的结构。化合物1和3-O-甲基醚在25mU时表现出轻微的抗乙肝病毒表面抗原活性。
Six homoflavonoids, ophioglonin (1), ophioglonin 7-O-beta-D-glucopyranoside (2), ophioglonol (3), ophioglonol prenyl ether (4), ophioglonol 4'-O-beta-D-glucopyranoside (5), and isoophioglonin 7-O-beta-D-glucopyranoside (6), together with five known compounds, quercetin, luteolin, kaempferol, 3,5,7,3',4'-pentahydroxy-8-prenylflavone, and quercetin 3-O-methyl ether, were isolated from Ophioglossum petiolatum. Their structures were elucidated by analysis of spectroscopic data and chemical evidence. Compounds 1 and quercetin 3-O-methyl ether showed slight anti-HBV surface antigen activity at 25 mu M.