HIGH-DOSE VITAMIN-C VERSUS PLACEBO IN THE TREATMENT OF PATIENTS WITH ADVANCED CANCER WHO HAVE HAD NO PRIOR CHEMOTHERAPY - A RANDOMIZED DOUBLE-BLIND COMPARISON
HIGH-DOSE VITAMIN-C VERSUS PLACEBO IN THE TREATMENT OF PATIENTS WITH ADVANCED CANCER WHO HAVE HAD NO PRIOR CHEMOTHERAPY - A RANDOMIZED DOUBLE-BLIND COMPARISON
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DOI：
10.1056/nejm198501173120301
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
AMES, MM
中科院分区：
文献类型：
--
作者：
MOERTEL, CG;FLEMING, TR;AMES, MM
有人声称，高剂量的维生素C对晚期癌症患者的治疗有益，特别是那些以前没有接受过化疗的患者。在一项双盲研究中，100名晚期结直肠癌患者被随机分配接受高剂量维生素C（每日10 g）或安慰剂治疗。总体而言，这些患者的一般状况非常好，症状轻微。无患者既往接受过任何细胞毒性药物治疗。维生素C治疗与安慰剂治疗相比，在治疗开始与疾病进展之间的时间间隔或患者生存率方面没有优势。在有可测量疾病的患者中，没有一个有客观改善。根据这项研究和以前的随机研究，可以得出结论，无论患者是否接受过任何化疗，大剂量维生素C治疗对晚期恶性疾病都无效。
It has been claimed that high-dose vitamin C is beneficial in the treatment of patients with advanced cancer, especially patients who have had no prior chemotherapy. In a double-blind study 100 patients with advanced colorectal cancer were randomly assigned to treatment with either high-dose vitamin C (10 g daily) or placebo. Overall, these patients were in very good general condition, with minimal symptoms. None had received any previous treatment with cytotoxic drugs. Vitamin C therapy showed no advantage over placebo therapy with regard to either the interval between the beginning of treatment and disease progression or patient survival. Among patients with measurable disease, none had objective improvement. On the basis of this and a previous randomized study, it can be concluded that high-dose vitamin C therapy is not effective against advanced malignant disease regardless of whether the patient has had any prior chemotherapy.