In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
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DOI：
10.1212/01.wnl.0000266626.64913.0f
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发表时间：
2007-07-24
期刊：
影响因子：
9.9
通讯作者：
Hansen, L. A.
中科院分区：
文献类型：
--
作者：
Weisman, D.;Cho, M.;Hansen, L. A.
我们使用尸检系列来确定最新的路易体痴呆（DLB）共识病理分类是否与DLB的死前诊断相关。用α-突触核蛋白抗体对总共95例路易体患者的新皮质切片进行染色。我们根据DLB共识的类别分配病例，发现与DLB的生前临床诊断有显著相关性。然而，DLB的临床诊断依赖于低阿尔茨海默病病理（Braak分期）的存在，而不是路易体分布。
We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB. Neocortical sections from a total of 95 cases with Lewy bodies were stained with alpha-synuclein antibodies. We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB. Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution.