Myometrium of the pregnant guinea pig: the probable importance of relaxin.
Myometrium of the pregnant guinea pig: the probable importance of relaxin.
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怀孕豚鼠的子宫肌层：松弛素的可能重要性。
DOI：
10.1093/biolreprod/7.3.458
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发表时间：
1972
影响因子：
3.6
通讯作者：
D. G. Porter
中科院分区：
文献类型：
--
作者：
D. G. Porter
未怀孕的豚鼠通过交叉循环与怀孕的豚鼠相连，记录宫内压力。观察到了一种频率调制效应，当怀孕的伴侣被另一只未怀孕的动物或雄性动物取代时，这种作用是不能表现出来的。起效快，停用交叉循环时持续时间短。据推测，在怀孕动物的血液中存在一种肌层抑制因子，由于所讨论的原因，它不可能是孕酮。猪松弛素(1 mg/h)的输注模拟了观察到的跨循环费用的变化，提示松弛素或松弛素样物质是豚鼠子宫肌层的主要调节因子。
Intrauterine pressure was recorded from nonpregnant guinea pigs linked to pregnant guinea pigs by cross circulation. A frequency-modulating effect was observed which could not be demonstrated when the pregnant partner was replaced by either another nonpregnant or a male animal. The effect was rapid in onset and was short lasting when cross circulation was discontinued. It was postulated that a myometrial inhibitory factor was present in the blood of the pregnant animal which for reasons discussed could not be progesterone. Infusions of porcine-relaxin (1 mg/h) simulated the changes observed in the cross-circulation expenments and the suggestion is made that relaxin or a relaxin-like substance or substances is a major myometrial regulating factor in the guinea pig.