Fat Grafting Subjectively Improves Facial Skin Elasticity and Hand Function of Scleroderma Patients.
Fat Grafting Subjectively Improves Facial Skin Elasticity and Hand Function of Scleroderma Patients.
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脂肪嫁接主观改善了硬皮病患者的面部皮肤弹性和手部功能。
DOI：
10.1097/gox.0000000000003373
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Cederna PS
中科院分区：
文献类型：
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作者：
Strong AL;Adidharma W;Brown OH;Cederna PS
补充数字内容可在文本中找到。系统性硬皮病是一种以内脏和皮肤纤维化为特征的慢性结缔组织病。不幸的是，有一个缺乏有效的治疗皮肤的表现，并应考虑替代干预。脂肪移植由于其再生特性和在改善皮肤质量和纤维化疾病中的体积缺陷方面的成功而获得了显著的关注。虽然一些研究已经调查了自体脂肪移植的功效，但是我们利用用于收获和处理的科尔曼方法来确定脂肪移植在改善硬皮病患者的手和面部中的皮肤纤维化而不过度处理脂肪组织的功效。纳入了2015年3月至2019年3月在密歇根大学接受脂肪移植的硬皮病患者。确定了10例符合入选标准的女性患者。手术时的平均年龄为48.7（± 17.6）岁。手部平均注射脂肪53.2（± 15.5）ml，面部平均注射脂肪26.1（± 16.4）ml。根据皮肤纤维化和体积不足的初始严重程度，对患者进行1-4轮移植治疗。脂肪移植主观和定性地改善了系统性硬皮病患者的口周皮肤质量、面部动画、手部活动范围和手部疼痛。未发现并发症。有必要进行更多的研究来确定理想的体积、治疗时机和脂肪类型，以优化自体脂肪移植治疗系统性硬皮病的疗效。
Supplemental Digital Content is available in the text. Systemic scleroderma is a chronic connective tissue disease characterized by internal organ and skin fibrosis. Unfortunately, there is a lack of efficacious treatments for cutaneous manifestations, and alternative interventions should be considered. Fat grafting has gained significant attention due to its regenerative properties and success in improving skin quality and volume deficits in fibrotic diseases. While some studies have investigated the efficacy of autologous fat grafting, we utilized the Coleman method for harvesting and processing to determine the efficacy of fat grafting to improve skin fibrosis in the hands and face of scleroderma patients without excess processing of adipose tissue. Patients with a diagnosis of scleroderma who underwent fat grafting between March 2015 and March 2019 at the University of Michigan were included. Ten female patients were identified that met inclusion criteria. The mean age at the time of surgery was 48.7 (± 17.6) years. An average of 53.2 (± 15.5) ml of fat was injected into the hands and 26.1 (± 16.4) ml into the face. Patients were treated with 1–4 rounds of grafting depending on the initial severity of skin fibrosis and volume deficiency. Fat grafting subjectively and qualitatively improved perioral skin quality, facial animation, hand range of motion, and hand pain for patients with systemic scleroderma. No complications were identified. Additional studies are necessary to determine the ideal volume, timing of treatments, and type of fat to optimize the efficacy of autologous fat grafting for the treatment of systemic scleroderma.