HLA A2601-restricted CTLs recognize a peptide antigen expressed on squamous cell carcinoma.
HLA A2601-restricted CTLs recognize a peptide antigen expressed on squamous cell carcinoma.
复制标题
HLA A2601 限制性 CTL 识别鳞状细胞癌上表达的肽抗原。
作者：
M. Nakao;H. Yamana;Y. Imai;Y. Toh;U. Toh;A. Kimura;S. Yanoma;T. Kakegawa;K. Itoh
在食管癌患者体内建立了针对自体肿瘤细胞的CD4-CD8+ CTL （KE-4 CTL）细胞系。通过对肿瘤细胞的细胞毒性、HLA A2601 cDNA转染实验和洗脱肽重组来评估，这种KE-4 CTL在HLA A2601限制的方式下识别了食管和肺鳞状细胞癌的肽抗原。正常细胞均未被该CTL溶解。这些结果表明，在食管癌患者的SCC上存在识别肽抗原的HLA a2601限制性CTL前体。
The CD4-CD8+ CTL (KE-4 CTL) cell line against autologous tumor cells was established in a patient with esophageal cancer. This KE-4 CTL recognized a peptide antigen on esophageal and lung squamous cell carcinomas in an HLA A2601-restricted manner, as evaluated by cytotoxicity against a panel of tumor cells, transfection experiments with HLA A2601 cDNA, and reconstitution with eluted peptides. None of the normal cells tested was lysed by this CTL. These results suggest the existence of HLA A2601-restricted CTL precursors recognizing a peptide antigen on SCC in a patient with esophageal cancer.
影响因子：
4.4
作者：
G. Peoples;P. Goedegebuure;J. Andrews;D. Schoof;T. Eberlein
通讯作者：
G. Peoples;P. Goedegebuure;J. Andrews;D. Schoof;T. Eberlein