Suppression of growth by dietary fish oil of human breast carcinomas maintained in three different strains of immune-deficient mice.
Suppression of growth by dietary fish oil of human breast carcinomas maintained in three different strains of immune-deficient mice.
复制标题
膳食鱼油对三种不同品系免疫缺陷小鼠中人类乳腺癌生长的抑制作用。
DOI：
10.1080/01635589309514278
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Welsch,MA
中科院分区：
文献类型：
--
作者：
Welsch,CW;Oakley,CS;Chang,CC;Welsch,MA
据报道，与玉米油相比，高水平的膳食鱼油（鲱鱼）抑制了雌性无胸腺裸小鼠（T淋巴细胞缺陷）中MDA-MB 231和MCF-7人乳腺癌的生长。本研究的目的是确定与玉米油相比，在雌性米色-XID-无胸腺裸小鼠（T淋巴细胞和NK/LAK细胞缺陷）和雌性严重联合免疫缺陷（SCID）小鼠（完全缺乏功能性T和B淋巴细胞）中，饮食鱼油是否也能抑制这些癌的生长。结果清楚地表明，在beige-XID-无胸腺裸鼠和SCID小鼠中，膳食鱼油可显著（p < 0.05）抑制这些癌的生长。这些结果提供了证据表明，由膳食鱼油诱导的MDA-MB 231和MCF-7人乳腺癌的生长抑制不是由涉及T淋巴细胞、B淋巴细胞和/或NK/LAK细胞的免疫系统机制介导的。
It has been reported that high levels of dietary fish (menhaden) oil, compared with corn oil, suppress the growth of MDA‐MB231 and MCF‐7 human breast carcinomas maintained in female athymic nude (T lymphocyte‐deficient) mice. The purpose of this study was to determine whether dietary fish (menhaden) oil, compared with corn oil, can also suppress the growth of these carcinomas when maintained in female beige‐XID‐athymic nude (T lymphocyte‐ and NK/LAK cell‐deficient) mice and in female severe combined immune‐deficient (SCID) mice (total lack of functional T and B lymphocytes). Results clearly show that dietary fish (menhaden) oil can significantly (p < 0.05) suppress the growth of these carcinomas in the beige‐XID‐athymic nude mouse and the SCID mouse. Such results provide evidence that the growth suppression of MDA‐MB231 and MCF‐7 human breast carcinomas, induced by dietary fish oil, is not mediated by immune system mechanisms involving T lymphocytes, B lymphocytes, and/or NK/LAK cells.