The effect of 8-methoxypsoralen and long-wave ultraviolet light on Langerhans cell.
The effect of 8-methoxypsoralen and long-wave ultraviolet light on Langerhans cell.
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8-甲氧基补骨脂素和长波紫外线对朗格汉斯细胞的影响。
DOI：
10.1111/1523-1747.ep12493242
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
T. Horio
中科院分区：
文献类型：
--
作者：
H. Okamoto;T. Horio
用ATP酶染色法观察了长波紫外线（PUVA）和8-甲氧基补骨脂素（8-methoxypropylene）对豚鼠Langerhans细胞的作用。ATP酶阳性朗格汉斯细胞的数量逐渐减少，直到PUVA处理后5至7天，当它被发现小于10%至20%的原始密度。甚至ATP酶阳性细胞也表现出异常的外观。树突状突起缩短或消失，中心体呈椭圆形或圆形。这些变化在14天后基本恢复正常。PUVA对接触性超敏反应的抑制作用可能与其对朗格汉斯细胞的影响有关。此外，对抗原呈递细胞的损伤可能加速PUVA诱导的肿瘤的发展。
The effect of 8-methoxypsoralen plus long-wave ultraviolet light (PUVA) on Langerhans cell was examined in guinea pigs using ATPase staining method. The number of ATPase-positive Langerhans cells gradually decreased until 5 to 7 days after PUVA treatment, when it was found to be less than 10% to 20% of the original density. Even the ATPase-positive cells exhibited abnormal appearance. The dendritic processes were shortened or disappeared and the central body became oval or round. These changes in population and morphology of Langerhans cell almost returned to normal by 14 days. The inhibitory effect of PUVA on the induction of contact hypersensitivity may be partly due to the alterations of Langerhans cells. Furthermore, the damage on the antigen-presenting cells may accelerate the development of PUVA-induced tumors.