Modulation of host immunity by tick saliva.
Modulation of host immunity by tick saliva.
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DOI：
10.1016/j.jprot.2015.07.005
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发表时间：
2015-10-14
影响因子：
3.3
通讯作者：
Chmelař J
中科院分区：
文献类型：
--
作者：
Kotál J;Langhansová H;Lieskovská J;Andersen JF;Francischetti IM;Chavakis T;Kopecký J;Pedra JH;Kotsyfakis M;Chmelař J
新一代测序和蛋白质组学有助于全面表征蜱唾液腺中转录组和蛋白质组水平的基因表达。然而，缺乏功能数据。鉴于蜱唾液分泌物是至关重要的成功蜱传播的生命周期，因此，宿主定植的病原体，他们传播，我们彻底审查在这里的文献蜱唾液（或蜱唾液腺提取物）和先天性和适应性脊椎动物免疫系统之间的已知相互作用。这些信息旨在作为一个参考的功能特性的众多基因和蛋白质表达的蜱唾液腺的最终目标，开发新的载体和病原体控制策略。
Next generation sequencing and proteomics have helped to comprehensively characterize gene expression in tick salivary glands at both the transcriptome and the proteome level. Functional data are, however, lacking. Given that tick salivary secretions are critical to the success of the tick transmission lifecycle and, as a consequence, for host colonization by the pathogens they spread, we thoroughly review here the literature on the known interactions between tick saliva (or tick salivary gland extracts) and the innate and adaptive vertebrate immune system. The information is intended to serve as a reference for functional characterization of the numerous genes and proteins expressed in tick salivary glands with an ultimate goal to develop novel vector and pathogen control strategies.