The avian telencephalic subpallium originates inhibitory neurons that invade tangentially the pallium (dorsal ventricular ridge and cortical areas)
The avian telencephalic subpallium originates inhibitory neurons that invade tangentially the pallium (dorsal ventricular ridge and cortical areas)
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DOI：
10.1006/dbio.2001.0422
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发表时间：
2001-11-01
影响因子：
2.7
通讯作者：
Martínez, S
中科院分区：
文献类型：
--
作者：
Cobos, I;Puelles, L;Martínez, S
哺乳动物新皮层发育的最新数据支持大多数抑制性GABA能中间神经元起源于软腭下（神经节隆起）。支持这种切向迁移到palaleurs来自实验，使用荧光示踪剂或谱系分析与逆转录病毒，和突变小鼠的表型与不同的异常发育subpaleurs。在本研究中，我们描述了切向迁移的subpallalalal-derived神经元在发育中的鸡端脑。使用鹌鹑鸡移植，我们精确地确定了神经上皮的起源，时间过程和迁移途径，以及不同的切向迁移神经元的身份和相对分布。苍白球和纹状体原基的选择性移植物的分析，使我们能够确定每个原基的迁移神经元的人口的相对贡献。此外，我们发现，像在哺乳动物中，绝大多数的GABA能和钙结合蛋白免疫反应神经元内的palelae（背侧脑室脊和皮质区）有一个皮质外，subpalelial起源。我们的研究结果表明，鸟类和哺乳动物的端脑共享其皮层中间神经元的起源和迁移的发育机制，这可能是在脊椎动物的辐射比以前认为的更早的阶段首先进化。(C)北京：科学出版社.
Recent data on the development of the mammalian neocortex support that the majority of its inhibitory GABAergic interneurons originate within the subpallium (ganglionic eminences). Support for such tangential migration into the pallium has come from experiments using fluorescent tracers or lineage analysis with retrovirus, and the phenotypes of mutant mice with different abnormalities in the developing subpallium. In the present study, we describe tangential migration of subpallial-derived neurons in the developing chick telencephalon. Using quail-chick grafts, we precisely identified the neuroepithelial origin, time-course, and pathways of migration, as well as the identity and relative distribution of the diverse tangentially migrated neurons. The analysis of selective grafts of the pallidal and striatal primordia allowed us to determine the relative contribution of each primordium to the population of migrating neurons. Moreover, we found that, like in mammals, the vast majority of the GABAergic and calbindin-immunoreactive neurons within the pallium (dorsal ventricular ridge and cortical areas) have an extracortical, subpallial origin. Our results suggest that the telencephalon of birds and mammals share developmental mechanisms for the origin and migration of their cortical interneurons, which probably first evolved at an earlier stage in the radiation of vertebrates than was thought before. (C) 2001 Academic Press.