Induction of peripheral blood T follicular helper cells expressing ICOS correlates with antibody response to hepatitis B vaccination
Induction of peripheral blood T follicular helper cells expressing ICOS correlates with antibody response to hepatitis B vaccination
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DOI：
10.1002/jmv.25585
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发表时间：
2020-01-01
影响因子：
12.7
通讯作者：
Lou, Xiaoming
中科院分区：
文献类型：
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作者：
Xing, Mingluan;Feng, Yonghui;Lou, Xiaoming
滤泡辅助性T细胞（TFH）是CD 4（+）T细胞的一个重要亚群，在生殖中心（GC）和滤泡外部位的体液免疫应答过程中为B细胞提供帮助。人循环血液中的CXCR 5（+）CD 4（+）T细胞，在本文中称为外周TFH（pTFH）细胞，与GC中的TFH细胞共享表型和功能特性。B型肝炎疫苗可保护约60%的慢性丙型肝炎患者免于感染B型肝炎。导致诱导保护性抗体应答的免疫学基础还不清楚。在本研究中，在18名健康对照（抗-HBs>= 100 mIU/mL; HC）、21名无应答者（抗-HBs < 10 mIU/mL; NR）和23名弱应答者（10 mIU/mL）中测定pTFH细胞亚群
T follicular helper (TFH) cells, a critical subset of CD4(+) T cells, provide help to B cells during the procession of the humoral immune response in the germinal center (GC) and extrafollicular sites. CXCR5(+)CD4(+) T cells in human circulating blood, referred to herein as peripheral TFH (pTFH) cells, share phenotypes and functional properties with TFH cells in GC. Hepatitis B vaccine protects about 60% of the chronic hepatitis C patients from hepatitis B. The immunological bases that lead to the induction of protective antibody response is not well understood. In the present study, the pTFH cells subsets were determined in 18 healthy controls (anti-HBs >= 100 mIU/mL; HC), 21 nonresponders (anti-HBs < 10 mIU/mL; NR), and 23 weak responders (10 mIU/mL