Developing a Rational Approach to Tobacco Use Treatment in Pulmonary Practice: A Review of the Biological Basis of Nicotine Addiction.
Developing a Rational Approach to Tobacco Use Treatment in Pulmonary Practice: A Review of the Biological Basis of Nicotine Addiction.
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DOI：
10.1097/cpm.0b013e318247cada
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发表时间：
2012-03-01
影响因子：
--
通讯作者：
Evers-Casey S
中科院分区：
文献类型：
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作者：
Leone FT;Evers-Casey S
烟草在肺部实践中使用的损失很严重。当看似不合理的决定以保持病态的肺部疾病，医生，患者及其家人在看似不合理的决定时会感到沮丧，绝望，甚至愤怒。本文研究了这种行为的生物学基础，并试图将这种洞察力纳入实践中问题的理性方法。尽管有理由停止，但在非理性强迫寻求尼古丁的框架内重新审查了吸烟。对烟雾强迫的控制被确定为重要的临床结果，并检查将烟草依赖作为慢性疾病的理由。最后，提出了对管理矛盾的实践见解，包括基于神经生物学的积极药物治疗方法。
The toll of tobacco use on a pulmonary practice is severe. Physicians, patients, and their families experience frustration, hopelessness and even anger when confronted with a seemingly irrational decision to keep smoking despite morbid lung disease. This paper examines the biological basis of this behavior and seeks to integrate this insight into a rational approach to the problem in practice. Smoking is reexamined within the framework of an irrational compulsion to seek nicotine, despite a rational desire to stop. Control over the compulsion to smoke is established as an important clinical outcome, and the rationale for treating tobacco dependence as a chronic illness is examined. Finally, practical insights into managing ambivalence, including an aggressive pharmacotheapeutic approach based on the neurobiology, are presented.