Nanobiotechnology-enabled energy utilization elevation for augmenting minimally-invasive and noninvasive oncology thermal ablation.
Nanobiotechnology-enabled energy utilization elevation for augmenting minimally-invasive and noninvasive oncology thermal ablation.
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DOI：
10.1002/wnan.1733
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发表时间：
2021-06
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影响因子：
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通讯作者：
Yan Zhang;Lehang Guo;Fanlei Kong;Lixia Duan;Hongyan Li;Chao Fang;Kun Zhang
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作者：
Yan Zhang;Lehang Guo;Fanlei Kong;Lixia Duan;Hongyan Li;Chao Fang;Kun Zhang
根据局部或靶向治疗、与肿瘤类型无关以及微创和无创的特点，各种热消融技术已经建立，但它们仍然遭受安全性和有效性之间的棘手矛盾。提高能量利用效率是降低热消融功率、缩短消融时间的主要手段，有利于同时提高治疗安全性和治疗效率，已被广泛接受。近年来，各种热治疗方法取得了重大进展，包括无创高强度聚焦超声、微创射频和微波、无创和微创光热消融等，特别是，采用各种纳米生物技术和设计方法来提高能量利用效率，以获得意想不到的消融结果，时间更重要的是，一些组合技术，例如化学疗法、光动力疗法（PDT）、气体疗法、声动力疗法（SDT）、免疫疗法、化学动力疗法（CDT）或催化纳米医学，被用于辅助这些消融手段来抑制或完全去除肿瘤。本文对这四种消融方法的消融原理和能量转化途径进行了讨论和总结，并对该领域的研究进展进行了回顾和评述，包括新开发的技术或新材料类型，重点介绍了受纳米生物技术启发的设计原理，并对存在的问题和发展方向进行了深入探讨。这篇文章分类下：治疗方法和药物发现>纳米医学肿瘤疾病治疗方法和药物发现>新兴技术.
Depending on the local or targeted treatment, independence on tumor type and minimally-invasive and noninvasive feature, various thermal ablation technologies have been established, but they still suffer from the intractable paradox between safety and efficacy. It has been extensively accepted that improving energy utilization efficiency is the primary means of decreasing thermal ablation power and shortening ablation time, which is beneficial for concurrently improving both treatment safety and treatment efficiency. Recent efforts have been made to receive a significant advance in various thermal methods including non-invasive high-intensity focused ultrasound, minimally-invasive radiofrequency and microwave, and non-invasive and minimally-invasive photothermal ablation, and so on. Especially, various nanobiotechnologies and design methodologies were employed to elevate the energy utilization efficiency for acquiring unexpected ablation outcomes accompanied with tremendously reduced power and time. More significantly, some combined technologies, for example, chemotherapy, photodynamic therapy (PDT), gaseous therapy, sonodynamic therapy (SDT), immunotherapy, chemodynamic therapy (CDT), or catalytic nanomedicine, were used to assist these ablation means to repress or completely remove tumors. We discussed and summarized the ablation principles and energy transformation pathways of the four ablation means, and reviewed and commented the progress in this field including newly developed technology or new material types with a highlight on nanobiotechnology-inspired design principles, and provided the deep insights into the existing problems and development direction. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.