Genetic contributors to obesity
Genetic contributors to obesity
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DOI：
10.1016/s0828-282x(07)71002-4
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发表时间：
2007-08-01
影响因子：
6.2
通讯作者：
McPherson, Ruth
中科院分区：
文献类型：
--
作者：
McPherson, Ruth
遗传和环境因素相互作用，调节体重。总体而言，肥胖的遗传率估计为40%至70%。超过244个基因被发现在小鼠中过度表达或缺失时强烈影响肥胖。这些基因可以被认为是在四大类：通过分子信号在下丘脑和后脑的脂肪组织，肠道和其他器官起源的信号调节食物摄入;调节脂肪细胞分化和脂肪储存;调节自发运动活动;和基础和餐后产热的影响。主要候选基因编码序列中的罕见变异导致5%至10%的个体具有肥胖表型。
Genetic and environmental factors interact to regulate body weight. Overall, the heritability of obesity is estimated at 40% to 70%. More than 244 genes have been found to strongly affect adiposity when overexpressed or deleted in mice. These genes can be considered in four broad categories: regulation of food intake by molecular signalling in the hypothalamus and hindbrain by signals originating in adipose tissue, gut and other organs; regulation of adipocyte differentiation and fat storage; regulation of spontaneous exercise activity; and effect on basal and postprandial thermogenesis. Rare variants in the coding sequences of major candidate genes account for an obese phenotype in 5% to 10% of individuals.