Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia
Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia
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DOI：
10.1016/s0920-9964(01)00165-7
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发表时间：
2002-01-01
影响因子：
4.5
通讯作者：
Deakin, JFW
中科院分区：
文献类型：
--
作者：
Chaudhry, IB;Soni, SD;Deakin, JFW
这项研究测试的假设，即非典型抗精神病药，以改善阴性症状的能力是由于5 HT受体拮抗作用和额叶功能增强。我们研究了赛庚啶（一种5-HT 2拮抗剂）对慢性精神分裂症患者额叶功能的神经心理学测试的影响。18例稳定的精神分裂症患者接受长效抗精神病药物治疗，参加了为期4周的双盲交叉研究。结果的措施是临床症状评定量表，神经心理学测试（语言流畅性，Stroop色词任务，线索）和antisaccade眼球运动。在赛庚啶阶段，Stroop色词任务、言语流畅性和Trail B测试有统计学显著改善。在反眼跳任务中，抑制对目标光的反射性眼动的能力也显著增强。这些患者的阴性症状临床评分较低，且不受赛庚啶的影响。结果表明，5 HT 2C受体选择性地调节速度和运动控制机制有关的额叶功能，但这是不相关的症状的变化。(C)2002 Elsevier Science B. V.保留所有权利。
This study tests the hypothesis that the ability of atypical neuroleptics to improve negative symptoms is due to 5HT-receptor antagonism and enhanced frontal lobe function. We investigated the effects of cyproheptadine (a 5HT2 antagonist) on neuropsychological tests of frontal lobe functions in chronic schizophrenic patients. Eighteen stable schizophrenic patients on depot neuroleptic medication participated in a 4-week double blind crossover study. Outcome measures were clinical symptoms rating scales, neuropsychological tests (verbal fluency, Stroop colour word task, trail making) and antisaccade eye movements. During the cyproheptadine phase statistically significant improvement was seen on Stroop colour word task, verbal fluency and Trail B tests. The ability to suppress reflexive eye movement to a target light in an anti saccade task was also significantly enhanced. The patients had low clinical ratings of negative symptoms and they were unaffected by cyproheptadine. The results indicate that 5HT2C receptors selectively modulate speed and motor control mechanisms related to frontal lobe functions but this was not associated with changes in symptoms. (C) 2002 Elsevier Science B.V. All rights reserved.