Studies toward the synthesis of Amaryllidaceae alkaloids from Morita-Baylis-Hillman adducts: a straightforward synthesis of functionalized dihydroisoquinolin-5(6H)-one core
Studies toward the synthesis of Amaryllidaceae alkaloids from Morita-Baylis-Hillman adducts: a straightforward synthesis of functionalized dihydroisoquinolin-5(6H)-one core
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DOI：
10.1590/s0103-50532007000700019
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发表时间：
2007-01-01
影响因子：
1.4
通讯作者：
Coelho, Fernando
中科院分区：
文献类型：
--
作者：
Lopes, Elizandra C.S.;Coelho, Fernando
我们在此披露了我们的研究结果，该研究旨在合成从石蒜科植物中分离出来的高取代生物碱的碳骨架。以Morita-Baylis-Hillman加合物为底物，合成了官能化二氢异喹啉-5(6H)-酮核，它是从该植物族中分离得到的生物碱结构的最底层部分。该化合物是从石蒜科植物中分离得到的生物碱的有效中间体。
We disclose herein our results concerning a study aiming at the synthesis of the highly substituted carbon skeleton of alkaloids isolated from plants of the Amaryllidaceae family. The total synthesis of the functionalized dihydroisoquinolin-5(6H)-one core, which is the bottom part of the structure of alkaloids isolated from this botanic family, is described, using Morita-Baylis-Hillman adducts as substrate. This compound should be a useful and valuable intermediate for the total synthesis of alkaloids isolated from Amaryllidaceae.