Histopathology and immunohistology of HTLV-III/LAV related lymphadenopathy and AIDS.
Histopathology and immunohistology of HTLV-III/LAV related lymphadenopathy and AIDS.
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HTLV-III/LAV 相关淋巴结病和艾滋病的组织病理学和免疫组织学。
DOI：
10.1111/j.1699-0463.1987.tb00009_95a.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
G. Biberfeld
中科院分区：
文献类型：
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作者：
P. Biberfeld;A. Öst;A. Porwit;B. Sandstedt;G. Pallesen;B. Böttiger;L. Morfelt;G. Biberfeld
我们对59例患有HTLV-III/LAV血清抗体的男同性恋者进行了详细的组织病理学和免疫组织化学研究。组织学检查结果与患者临床状态、血液和淋巴结T4/T8比值相关。四种主要的组织学模式被定义为滤泡增生（FH）、滤泡破碎（FF）、滤泡萎缩（FA）和滤泡耗竭（FD）。免疫细胞化学研究表明，卵泡树突状细胞的破坏与卵泡从FH到FF的退化有关，但不能排除滤泡浸润性t细胞的可能作用。在复发过程中，观察到淋巴结血管生成增加的显著个体差异，这表明血管生成宿主反应的程度可能易导致卡波西肉瘤的进化。临床上诊断为持续性广泛性淋巴结病（PGL）的患者，绝大多数形态学分期为FH或FF(89%)，而大多数艾滋病患者表现为FA和FD相容的淋巴结改变（89%）。AIDS-related complex （ARC）患者有更广泛的淋巴结形态学改变，但大多数病例（62%）也被归类为FA或FD。临床随访显示，21例FF型患者中有7例从PGL发展为ARC，而19例FH型患者中仅有3例，提示区分FH和FF可能具有预后价值。3例FD和1例FA在观察期间发展为艾滋病。与其他组织学组相比，FD组患者血液和淋巴结T4/T8比值明显降低。尸检时，所有艾滋病病例均表现为FD型淋巴结病。7名患者的尸检结果强调了验尸后研究在澄清机会性疾病谱系方面的重要性，包括折磨艾滋病患者的肿瘤。
Fifty-nine lymph node biopsies from homosexual men with serum antibodies to HTLV-III/LAV were the subject of a detailed histopathological and immunohistochemical study. The histological findings were correlated to the patients clinical status, and the T4/T8 ratios in blood and lymph nodes. Four histological patterns predominated and were defined as follicular hyperplasia (FH), follicular fragmentation (FF), follicular atrophy (FA), and follicular depletion (FD). Immunocytochemical studies indicated that destruction of follicular dendritic cells is related to the initiation of follicular involution from FH to FF, but the possible role of follicular infiltrating T-cells cannot be excluded. Marked individual variations in lymph node angiogenesis increasing during involution were observed, which suggests that the degree of angiogenic host response may predispose for evolution of Kaposi's sarcoma. The majority of the patients with the clinical diagnosis of persistent generalized lymphadenopathy (PGL) were morphologically staged as FH or FF (89%), whereas most of the AIDS patients showed lymph node changes compatible with FA and FD (89%). Patients with AIDS-related complex (ARC) had a wider spectrum of morphological lymph node changes but a majority of cases (62%) were also classified as FA or FD. Clinical follow-up showed progression from PGL to ARC in seven of 21 cases with the FF pattern and only in three of 19 cases with FH, indicating a possible prognostic value in differentiating between FH and FF. Three cases with FD and one with FA progressed to AIDS during the time of observation. T4/T8 ratios in blood and lymph nodes were significantly lower in patients with FD histology compared to patients of the other histological groups. At autopsy, all AIDS cases showed the FD pattern of lymphadenopathy. Autopsy findings in seven patients emphasized the importance of post-mortem studies in clarifying the spectrum of opportunistic diseases, including tumors which afflict the AIDS patients.
男性同性恋者的逆转录病毒和恶性淋巴瘤。
DOI：
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发表时间：
1985
期刊：
JAMA : the journal of the American Medical Association
影响因子：
--
作者：
Levine,AM;Gill,PS;Meyer,PR;Burkes,RL;Ross,R;Dworsky,RD;Krailo,M;Parker,JW;Lukes,RJ;Rasheed,S
通讯作者：
Rasheed,S