RECEPTIVE-FIELD DYNAMICS IN ADULT PRIMARY VISUAL-CORTEX
RECEPTIVE-FIELD DYNAMICS IN ADULT PRIMARY VISUAL-CORTEX
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DOI：
10.1038/356150a0
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发表时间：
1992-03-12
期刊：
影响因子：
64.8
通讯作者：
WIESEL, TN
中科院分区：
文献类型：
--
作者：
GILBERT, CD;WIESEL, TN
成年人的大脑具有适应感官输入变化的非凡能力。去除体感、听觉、运动或视觉皮层的传入输入会导致皮层地形的显著变化1-10。感觉活动的变化可以在几个月的时间内改变感受野的大小和皮层地形。在这里，我们通过局灶性双眼视网膜病变去除视觉输入，并在病变前和病变后几分钟内从相同的皮质部位记录，发现在视网膜暗瘤边缘附近的皮质细胞的感受野大小立即显著增加。几个月后，甚至最初因病变而沉默的皮质区域也恢复了视觉活动，代表病变周围的视网膜位置。在向纹状皮层提供视觉输入的外侧膝状核的水平上，有一个很大的沉默区。此外，解剖学研究表明，源性皮层传入事件的扩散不足以解释皮层的恢复。结果表明，皮层内的地形重组主要是由于皮层固有的突触变化，可能是通过远距离水平连接的神经丛。
THE adult brain has a remarkable ability to adjust to changes in sensory input. Removal of afferent input to the somatosensory, auditory, motor or visual cortex results in a marked change of cortical topography 1-10. Changes in sensory activity can, over a period of months, alter receptive field size and cortical topography 11. Here we remove visual input by focal binocular retinal lesions and record from the same cortical sites before and within minutes after making the lesion and find immediate striking increases in receptive field size for cortical cells with receptive fields near the edge of the retinal scotoma. After a few months even the cortical areas that were initially silenced by the lesion recover visual activity, representing retinotopic loci surrounding the lesion. At the level of the lateral geniculate nucleus, which provides the visual input to the striate cortex, a large silent region remains. Furthermore, anatomical studies show that the spread of geniculocortical afferents is insufficient to account for the cortical recovery. The results indicate that the topographic reorganization within the cortex was largely due to synaptic changes intrinsic to the cortex, perhaps through the plexus of long-range horizontal connections.