Robustness and Specificity in Signal Transduction via Physiologic Protein Interaction Networks.
Robustness and Specificity in Signal Transduction via Physiologic Protein Interaction Networks.
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DOI：
10.4172/2161-1459.s3-001
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发表时间：
2012-12-21
期刊：
影响因子：
--
通讯作者：
Gil D
中科院分区：
文献类型：
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作者：
Schrum AG;Gil D
集体蛋白质：细胞的蛋白质相互作用（PPI）被认为代表了一个具有紧急网络特性的系统，该系统将来自多种输入的信号整合为协调响应。据推测，PPI网络对许多利用共同中间通路的不同信号提供特异性，并通过允许特定信号通过替代途径进行通信提供鲁棒性。遗传网络的进展指向了这些概念，但由于缺乏此类评估所需的定量数据，PPI网络具有这些特性的程度尚未经过经验测试。在这里，一个假设的生理性PPI网络被用来说明信号鲁棒性和特异性如何在(i)缺失突变或（ii）由于环境条件或刺激的变化而导致的信号变化的条件下表现出来。作者认为，能够对PPI网络原理进行实证分析的技术进步将有可能显著影响对信号机制的基本理解，并有助于在药物筛选和药理学方面产生新的应用。
The collective Protein:Protein Interactions (PPI) of a cell are thought to represent a system with emergent network properties that integrate signals from a multiplicity of inputs into coordinated responses. It is hypothesized that the PPI network supplies both specificity for many distinct signals that utilize common intermediate pathways, and also robustness by allowing specific signals to be communicated by alternate routes. Progress with genetic networks points to these concepts, but the extent to which PPI networks possess these properties has not been empirically tested, due to lack of quantitative data needed for such assessments. Here, a hypothetical physiologic PPI network is used to illustrate how signaling robustness and specificity could be manifest under conditions of (i) deletion mutation, or (ii) changes in signaling due to variation in environmental conditions or stimuli. It is proposed that advances in technology enabling empirical analysis of PPI network principles will have the potential to significantly impact basic understanding of signaling mechanisms, and contribute to the generation of novel applications in drug screening and pharmacology.