Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns
Complete blood count parameters for healthy, small-for-gestational-age, full-term newborns
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DOI：
10.1111/j.1365-2257.2006.00767.x
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发表时间：
2006-04-01
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影响因子：
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通讯作者：
Özbek, N
中科院分区：
文献类型：
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作者：
Özyürek, E;Çetintas, S;Özbek, N
之前没有研究调查过小胎龄（SGA）新生儿全血细胞计数（CBC）参数的全范围。本研究的主要目的是比较足月、健康SGA新生儿和适胎龄（AGA）新生儿的CBC和外周涂片参数，并建立足月SGA新生儿的CBC参考值。纳入132名健康足月新生儿（73名SGA和59名AGA）。第1天取109个样本，第7天取77个样本。对收集的每个样本进行全血细胞计数和外周涂片分析，并比较各组数据。我们观察到，在第1天，SGA婴儿的正常细胞计数、血红蛋白、红细胞压积和红细胞（RBC）计数的平均值高于AGA婴儿。我们观察到SGA婴儿的红细胞计数和平均红细胞体积相对较高，因此红细胞血红蛋白平均值和平均红细胞血红蛋白浓度值降低。在SGA新生儿中，21.9%有中性粒细胞减少症，4.7%在第1天绝对中性粒细胞计数低于1500/ μ l。在第1天和第7天，SGA新生儿的平均绝对超髓细胞计数和平均I: T（未成熟：总中性粒细胞比率）值均高于AGA组。SGA组婴儿在第7天的平均绝对淋巴细胞计数低于AGA组。我们在第1天检测的64名SGA新生儿中检测到近三分之一的血小板减少症。总之，我们的研究清楚地表明，健康足月SGA新生儿的CBC参数与健康足月AGA新生儿的CBC参数不同。这是第一个记录SGA婴儿与AGA婴儿不同的平均红细胞体积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度、超髓细胞计数、淋巴细胞计数和I: T的研究。
No previous study has investigated the full range of complete blood count (CBC) parameters in small-for-gestational-age (SGA) newborns. The main aim of this study was to compare CBC and peripheral smear parameters in term, healthy SGA neonates and appropriate-for-gestational-age (AGA) neonates, and to establish CBC reference values for full-term SGA newborns. One hundred thirty-two healthy, term newborns (73 SGA and 59 AGA) were included. On day 1, we obtained 109 samples and on day 7 we obtained 77 samples. A CBC and peripheral smear were analyzed for each sample collected and group data were compared. We observed higher mean values for normoblast count, hemoglobin, hematocrit, and red blood cell (RBC) count in the SGA babies than in the AGA babies on day 1. The mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration values for the SGA babies were decreased because of the relatively high RBC count and relatively high mean corpuscular volume we observed in this group. Of the SGA newborns, 21.9% had neutropenia and 4.7% had absolute neutrophil counts lower than 1500/mu l on day 1. On both day 1 and day 7, the SGA newborns had higher mean absolute metamyelocyte counts and higher mean I : T (immature : total neutrophil ratio) values than the AGA group. The SGA babies had a lower mean absolute lymphocyte count on day 7 than the AGA group. We detected thrombocytopenia in almost one-third of the 64 SGA newborns tested on day 1. In summary, our study clearly demonstrates that CBC parameters for healthy, full-term, SGA newborns are different from those of healthy, term AGA newborns. This is the first study that has documented different mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, metamyelocyte counts, lymphocyte counts, and I : T in SGA babies compared with AGA babies.