The neurobiology of cognitive disorders in temporal lobe epilepsy.
The neurobiology of cognitive disorders in temporal lobe epilepsy.
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DOI：
10.1038/nrneurol.2011.3
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发表时间：
2011-03
影响因子：
38.1
通讯作者：
Hermann, Bruce
中科院分区：
文献类型：
--
作者：
Bell, Brian;Lin, Jack J.;Seidenberg, Michael;Hermann, Bruce
认知障碍，尤其是记忆中断是癫痫的一个主要复杂特征。在这篇综述中，我们开始的重点是颞叶癫痫的记忆障碍的问题。我们首先简要概述了知识的早期发展有关颞叶癫痫的记忆障碍的解剖学基础，然后讨论随着时间的推移，知识的细化癫痫手术（前颞叶切除术）的结果和临床努力，以预测那些患者在最大的风险，不良认知结果癫痫手术后通知。这些努力也产生了新的理论见解，人类海马体的功能和这些见解的一些例子被简单地触及。最后，颞叶癫痫的巨大变化的观点进行了检查，包括研究结果表明，解剖异常延伸到颞叶以外，认知障碍延伸到记忆功能之外，这些分布的认知和解剖异常的联系指向癫痫认知障碍的解剖结构的新认识。挑战仍然存在于理解这些认知和解剖异常的起源，它们随着时间的推移而发展，最重要的是，如何干预以保护癫痫患者的认知和大脑健康。
Cognitive impairment and especially memory disruption is a major complicating feature of the epilepsies. In this review we begin with a focus on the problem of memory impairment in temporal lobe epilepsy. We start with a brief overview of the early development of knowledge regarding the anatomic substrates of memory disorder in temporal lobe epilepsy, followed by discussion of the refinement of that knowledge over time as informed by the outcomes of epilepsy surgery (anterior temporal lobectomy) and the clinical efforts to predict those patients at greatest risk of adverse cognitive outcomes following epilepsy surgery. These efforts also yielded new theoretical insights regarding the function of the human hippocampus and a few examples of these insights are touched on briefly. Finally, the vastly changing view of temporal lobe epilepsy is examined including findings demonstrating that anatomic abnormalities extend far outside the temporal lobe, cognitive impairments extend beyond memory function, with linkage of these distributed cognitive and anatomic abnormalities pointing to a new understanding of the anatomic architecture of cognitive impairment in epilepsy. Challenges remain in understanding the origin of these cognitive and anatomic abnormalities, their progression over time, and most importantly, how to intervene to protect cognitive and brain health in epilepsy.
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DOI：
10.1017/s1355617797004359
发表时间：
1997-09-01
影响因子：
2.6
作者：
Barr, William B.;Chelune, Gordon J.;Westerveld, Michael
通讯作者：
Westerveld, Michael
影响因子：
5.6
作者：
Binder, Jeffrey R.;Sabsevitz, David S.;Mueller, Wade M.
通讯作者：
Mueller, Wade M.
影响因子：
9.9
作者：
CHELUNE, GJ;NAUGLE, RI;AWAD, IA
通讯作者：
AWAD, IA
DOI：
10.3174/ajnr.a1650
发表时间：
2009-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ahmadi ME;Hagler DJ Jr;McDonald CR;Tecoma ES;Iragui VJ;Dale AM;Halgren E
通讯作者：
Halgren E
影响因子：
9.9
作者：
Bernasconi, N;Bernasconi, A;Reutens, DC
通讯作者：
Reutens, DC