Ultrasonic tissue characterization of prostate biopsy tissues by ultrasound speed microscope
Ultrasonic tissue characterization of prostate biopsy tissues by ultrasound speed microscope
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通过超声速度显微镜对前列腺活检组织进行超声组织表征
DOI：
10.1109/iembs.2011.6092097
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Saijo Y
中科院分区：
文献类型：
--
作者：
Tanoue H;Hagiwara Y;Kobayashi K;Saijo Y
为了定量测量软组织的超声参数，研制了超声速度显微镜。该系统可以利用单个脉冲波的快速傅里叶变换来测量组织中的超声衰减和声速，而不是传统的声学显微镜中使用的突发波。前列腺活检组织用福尔马林固定，切片厚度约5-6μm。它们被安装在没有盖片的玻璃幻灯片上。超声波换能器在样品上进行机械扫描。前列腺癌声学衰减为1.42±0.08dB/mm，声速为1584±12m/S，而正常前列腺癌为1.86±0.14db/mm和1614±30m/S。超声特性的基本测量有助于理解临床超声对前列腺癌诊断的解释。
Ultrasound speed microscope was developed for quantitative measurement of ultrasonic parameters of soft tissues. The system can measure the ultrasonic attenuation and sound speed in the tissue using fast Fourier transform of a single pulsed wave instead of burst waves used in conventional acoustic microscopy. Prostate biopsy tissues were formalin-fixed and sectioned approximately 5-6 μm in thickness. They were mounted on glass slides without cover slips. The ultrasonic transducer was mechanically scanned over the specimen. Attenuation was 1.42±0.08 dB/mm and the sound speed was 1584±12 m/s in prostatic cancer while both values were 1.86±0.14 dB/mm and 1614±30 m/s in normal prostate. The basic measurements of ultrasonic properties would help understanding the interpretation of clinical echography in diagnosis of prostate cancer.