ENHANCEMENT OF MORPHINE-INDUCED ANALGESIA AND ATTENUATION OF MORPHINE-INDUCED SIDE-EFFECTS BY COCAINE IN RATS
ENHANCEMENT OF MORPHINE-INDUCED ANALGESIA AND ATTENUATION OF MORPHINE-INDUCED SIDE-EFFECTS BY COCAINE IN RATS
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DOI：
10.1111/j.1600-0773.1992.tb00540.x
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发表时间：
1992-09-01
期刊：
影响因子：
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通讯作者：
PERTOVAARA, A
中科院分区：
文献类型：
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作者：
KAUPPILA, T;MECKE, E;PERTOVAARA, A
研究了可卡因对吗啡致大鼠镇痛及呼吸抑制、心动过缓、低运动/镇静的影响。研究戊巴比酮诱导麻醉对心血管和呼吸的影响。在正常大鼠福尔马林实验、骨板实验和热断尾实验中，可卡因增强吗啡诱导的镇痛作用。然而，在脊髓大鼠中，可卡因与吗啡的类似组合并没有在尾巴戒断测试中产生增加的潜伏期。在使用的三种镇痛试验中，福尔马林试验对增强效果以及单独使用吗啡或可卡因的效果最为敏感。6 mg/kg吗啡在福尔马林试验中产生完全镇痛，明显的低运动/镇静作用，明显的心动过缓，呼吸速率明显降低。在吗啡(3mg /kg)-可卡因（5mg /kg）等镇痛剂量（福尔马林试验中完全镇痛）组合时，未观察到心率、呼吸频率或运动（/警觉性）的显著变化。在任何实验条件下，激光多普勒血流法测定的皮肤血流变化均不显著。结果表明，可卡因增强吗啡诱导的镇痛，主要是由于棘上机制。相反，吗啡引起的呼吸缓慢、心动过缓和低运动/镇静被可卡因减弱。
Effect of cocaine on morphine-induced analgesia and the accompanying respiratory depression, bradycardia and hypolocomotion/sedation was studied in rats. Cardiovascular and respiratory effects were studied under pentobarbitone-induced anaesthesia. Cocaine enhanced morphine-induced analgesia in the formalin test, bot plate test and heat-induced tail withdrawal test in intact rats. However, in spinal rats a similar combination of cocaine with morphine did not produce increased latencies in the tail withdrawal test. Of the three analgesic tests used, the formalin test was the most sensitive to the enhancement, as well as to the effects of morphine or cocaine alone. Morphine at the dose of 6 mg/kg produced complete analgesia in the formalin test, significant hypolocomotion/sedation, significant bradycardia and significant decrease in the respiratory rate. At an equianalgesic dose (complete analgesia in the formalin test) of morphine (3 mg/kg)-cocaine (5 mg/kg)-combination no significant changes in heart rate, respiratory rate or locomotion(/alertness) were observed. Changes in skin blood flow determined by the laser Doppler flow method were not significant in any of the experimental conditions. The results indicate that cocaine enhances morphine-induced analgesia, mainly due to supraspinal mechanisms. In contrast, the morphine-induced bradypnoea, bradycardia and hypolocomotion/sedation are attenuated by cocaine.