Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery
Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery
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DOI：
10.1016/j.carres.2011.03.019
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发表时间：
2011-09-06
影响因子：
3.1
通讯作者：
Toth, Istvan
中科院分区：
文献类型：
--
作者：
Ziora, Zyta M.;Wimmer, Norbert;Toth, Istvan
报道了一类糖脂肽作为构建新型动态组合文库的结构单元。文库的成员由可变碳水化合物部分、编码氨基酸和脂氨基酸组成，以便将它们转化为两亲物。糖肽两亲物在水相中通过非共价键相互作用，形成动态密排流体镶嵌阵列胶束。两亲物的头部基团暴露在胶束表面上，提供可以在生物测定中筛选的实体，以找到最有效的结构单元组合，从而鉴定新的生物活性碳水化合物配体。(C)2011爱思唯尔有限公司保留所有权利。
A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands. (C) 2011 Elsevier Ltd. All rights reserved.